| General Information of Drug-Metabolizing Enzyme (DME ID: DME0113) |
| DME Name |
Heparanase (HPSE), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.2.1.166 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.166
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Fusobacteria |
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| Streptobacillus moniliformis (fusobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Heparin |
Click to Show/Hide the Detail |
| Drug ID |
DR0806
Drug Info
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| Interaction Mechanism |
Human Heparanase (HPSE) and Streptobacillus moniliformis co-metabolize the drug Heparin, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2], [3] |
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| References |
| 1 |
Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin. J Allergy Clin Immunol. 2011 Dec;128(6):1310-1317.e8.
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| 2 |
A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
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| 3 |
A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports
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