| General Information of Drug-Metabolizing Enzyme (DME ID: DME0117) |
| DME Name |
Dehydropeptidase-I (DPEP1), Homo sapiens
|
DME Info
|
| UniProt ID |
|
| EC Number |
EC: 3.4.13.19 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Dipeptidase
EC: 3.4.13.19
|
| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
|
| Interactome |
|
| Interactions between Microbiome and DME (MICBIO)
|
| Bacteria: Proteobacteria |
|---|
| Enterobacter cloacae (enterobacteria) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
|
| Doripenem |
Click to Show/Hide the Detail |
| Drug ID |
DR0534
Drug Info
|
| Interaction Mechanism |
Human Dehydropeptidase-I (DPEP1) and Enterobacter cloacae co-metabolize the drug Doripenem, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
|
|
|
|
|
|
| References |
| 1 |
Disposition, metabolism, and excretion of [14C]doripenem after a single 500-milligram intravenous infusion in healthy men. Antimicrob Agents Chemother. 2008 Oct;52(10):3478-83.
|
| 2 |
FRI-4 carbapenemase-producing Enterobacter cloacae complex isolated in Tokyo, Japan. J Antimicrob Chemother. 2018 Nov 1;73(11):2969-2972.
|
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.
