| General Information of Drug-Metabolizing Enzyme (DME ID: DME0197) |
| DME Name |
Aldo-keto reductase 1C1 (AKR1C1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.1.1.149 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.149
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Firmicutes |
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| Bacillus megaterium (firmicutes) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Progesterone |
Click to Show/Hide the Detail |
| Drug ID |
DR1346
Drug Info
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| Interaction Mechanism |
Human Aldo-keto reductase 1C1 (AKR1C1) and Bacillus megaterium co-metabolize the drug Progesterone, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43.
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| 2 |
acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
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