Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0230)
DME Name Tartrate-resistant acid ATPase (ACP5), Homo sapiens DME Info
UniProt ID
PPA5_HUMAN
EC Number    EC: 3.1.3.2     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Bacillus subtilis (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Tartrate-resistant acid ATPase (ACP5) and Bacillus subtilis co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                  Staphylococcus aureus (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Tartrate-resistant acid ATPase (ACP5) and Staphylococcus aureus co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [3]
      Bacteria: Proteobacteria
                  Salmonella typhimurium (enterobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Riboflavin Click to Show/Hide the Detail
                                 Drug ID DR1416   Drug Info
                                 Interaction Mechanism Human Tartrate-resistant acid ATPase (ACP5) and Salmonella typhimurium co-metabolize the drug Riboflavin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [4], [5]
References
1 An atlas of human metabolism. Sci Signal. 2020 Mar 24;13(624). pii: eaaz1482. (Reaction HMR_6507)
2 Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J Bacteriol. 1998 Jan;180(2):422-5.
3 Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500.
4 Purification and characterization of wild-type and mutant "classical" nitroreductases of Salmonella typhimurium. L33R mutation greatly diminishes binding of FMN to the nitroreductase of S. typhimurium. J Biol Chem. 1998 Sep 11;273(37):23922-8.
5 Prenatal diagnosis of junctional epidermolysis bullosa Herlitz type. Lancet. 1989 Oct 28;2(8670):1035-6. Letter

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