General Information of Drug-Metabolizing Enzyme (DME ID: DME0308)
DME Name Glutathione S-transferase mu-1 (GSTM1), Homo sapiens DME Info
UniProt ID
GSTM1_HUMAN
EC Number    EC: 2.5.1.18     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Bacteroidetes
                  Prevotella copri (CFB bacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Carboplatin Click to Show/Hide the Detail
                                 Drug ID DR0272   Drug Info
                                 Interaction Mechanism Human Glutathione S-transferase mu-1 (GSTM1) and Prevotella copri co-metabolize the drug Carboplatin, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
2 revotella copri is associated with carboplatin-induced gut toxicity. Cell Death Dis. 2019 Sep 26;10(10):714.

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