Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0545)
DME Name Lecithin-cholesterol acyltransferase (LCAT), Homo sapiens DME Info
UniProt ID
LCAT_HUMAN
EC Number    EC: 2.3.1.43     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.43
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Actinobacteria
                  Bifidobacterium angulatum (actinobacteria) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Phosphatidylcholine Click to Show/Hide the Detail
                                 Drug ID DR2122   Drug Info
                                 Interaction Mechanism Human Lecithin-cholesterol acyltransferase (LCAT) and Bifidobacterium angulatum co-metabolize the drug Phosphatidylcholine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
      Bacteria: Firmicutes
                  Lactobacillus acetotolerans (firmicutes) Click to Show/Hide the Full List of Drugs:        1 Drugs Metabolized
                              Phosphatidylcholine Click to Show/Hide the Detail
                                 Drug ID DR2122   Drug Info
                                 Interaction Mechanism Human Lecithin-cholesterol acyltransferase (LCAT) and Lactobacillus acetotolerans co-metabolize the drug Phosphatidylcholine, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
References
1 Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line. Protein Expr Purif. 2004 Aug;36(2):157-64.
2 Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio. 2016 Apr 5;7(2):e02210-15.

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