Details of Microbiome-DME Interaction (MICBIO)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0578)
DME Name Sorbitol dehydrogenase (SORD), Homo sapiens DME Info
UniProt ID
DHSO_HUMAN
EC Number    EC: 1.1.1.14     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.14
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Interactions between Microbiome and DME (MICBIO)
      Bacteria: Firmicutes
                  Anaerobutyricum hallii (firmicutes) Click to Show/Hide the Full List of Drugs:        2 Drugs Metabolized
                              Fructose Click to Show/Hide the Detail
                                 Drug ID DR1932   Drug Info
                                 Interaction Mechanism Human Sorbitol dehydrogenase (SORD) and Anaerobutyricum hallii co-metabolize the drug Fructose, which can collectively affect efficacy, safety or bioavailability of this drug. [1], [2]
                              Sorbitol Click to Show/Hide the Detail
                                 Drug ID DR1933   Drug Info
                                 Interaction Mechanism Human Sorbitol dehydrogenase (SORD) and Anaerobutyricum hallii co-metabolize the drug Sorbitol, which can collectively affect efficacy, safety or bioavailability of this drug. [3], [2]
References
1 Isolation, characterization and evaluation of the Pichia pastoris sorbitol dehydrogenase promoter for expression of heterologous proteins. Protein Expr Purif. 2013 Nov;92(1):128-33.
2 Reclassification of Eubacterium hallii as Anaerobutyricum hallii gen. nov., comb. nov., and description of Anaerobutyricum soehngenii sp. nov., a butyrate and propionate-producing bacterium from infant faeces. Int J Syst Evol Microbiol. 2018 Dec;68(12):3741-3746.
3 Plasma concentration of iditol dehydrogenase (sorbitol dehydrogenase) in ponies treated with aflatoxin B1. Am J Vet Res. 1980 Jun;41(6):925-7.

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