| General Information of Drug-Metabolizing Enzyme (DME ID: DME0613) |
| DME Name |
Glutathione S-transferase mu-4 (GSTM4), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Microbiome and DME (MICBIO)
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| Bacteria: Firmicutes |
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| Bacillus megaterium (firmicutes) |
Click to Show/Hide the Full List of Drugs: 1 Drugs Metabolized
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| Amodiaquine |
Click to Show/Hide the Detail |
| Drug ID |
DR0102
Drug Info
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| Interaction Mechanism |
Human Glutathione S-transferase mu-4 (GSTM4) and Bacillus megaterium co-metabolize the drug Amodiaquine, which can collectively affect efficacy, safety or bioavailability of this drug. |
[1], [2] |
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| References |
| 1 |
Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: possible implications for susceptibility to amodiaquine-induced liver toxicity. Toxicol Lett. 2017 Jun 5;275:83-91.
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| 2 |
The bacterial P450 BM3: a prototype for a biocatalyst with human P450 activities. Trends Biotechnol. 2007 Jul;25(7):289-98.
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