| General Information of Drug-Metabolizing Enzyme (DME ID: DME0056) |
| DME Name |
Carboxylesterase 3 (CES3), Homo sapiens
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DME Info
|
| UniProt ID |
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| EC Number |
EC: 3.1.1.1 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Carboxylic ester hydrolase
EC: 3.1.1.1
|
| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Xenobiotics and DME (XEOTIC)
|
| Health or Environmental Toxicant(s) |
|---|
| Acute Toxic Substance |
Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
|
| Phenylmethylsulfonyl fluoride |
Click to Show/Hide the Detail |
Inhibition |
| XEOTIC ID |
XEO01427
XEOTIC Info
|
Gene Form |
mRNA |
| Classification |
Acute Toxic Substance |
| DME Modulation |
Phenylmethylsulfonyl fluoride inhibits the expression of DME CES3 |
[1] |
| Natural Product(s), Extract(s) or Medicine(s) |
|---|
| Plant Extract |
Click to Show/Hide the Full List of Xenobiotics: 1 Xenobiotics
|
| Plant extracts |
Click to Show/Hide the Detail |
Inhibition |
| XEOTIC ID |
XEO01574
XEOTIC Info
|
Gene Form |
Protein |
| Classification |
Plant Extract |
| DME Modulation |
Plant extracts inhibits the drug-metabolizing activity of DME CES3 |
[2] |
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| References |
| 1 |
Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
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| 2 |
Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
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