General Information of Xenobiotics (ID: XEO01574)
Xenobiotics Name
Plant extracts
Xenobiotics Type
Natural Product(s), Extract(s) or Medicine(s)
Classification
Plant Extract
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1], [2]
Aquaporin adipose (AQP7) DME Info Homo sapiens [3]
Serine sulfhydrase (CBS) DME Info Homo sapiens [4], [5]
Carboxylesterase 3 (CES3) DME Info Homo sapiens [6]
Steroid 17-alpha-monooxygenase (CYP17A1) DME Info Homo sapiens [7]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [8]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [9]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [10], [11]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DME Info Homo sapiens [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [12]
Cytochrome P450 2C18 (CYP2C18) DME Info Homo sapiens [12], [13]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [8]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [14]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [15]
Cytochrome P450 3A7 (CYP3A7) DME Info Homo sapiens [16]
Cytochrome P450 4B1 (CYP4B1) DME Info Homo sapiens [15]
Folylpolyglutamate synthase (FPGS) DME Info Homo sapiens [17]
Sodium/potassium-transporting ATPase gamma (FXYD2) DME Info Homo sapiens [17]
Methionine-tRNA ligase mitochondrial (MARS2) DME Info Homo sapiens [18]
Nitric oxide synthase brain (NOS1) DME Info Homo sapiens [19]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [20]
Steroid 5-alpha-reductase 1 (SRD5A1) DME Info Homo sapiens [17]
Thymidylate synthase (TYMS) DME Info Homo sapiens [21]
Uridine 5'-monophosphate synthase (UMPS) DME Info Homo sapiens [21]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [22]
DME(s) Induced by This Xenobiotics
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [23]
Pancreatic alpha-amylase (AMY2A) DME Info Homo sapiens [17]
Catalase (CAT) DME Info Homo sapiens [23]
Vitamin D(3) 24-hydroxylase (CYP24A1) DME Info Homo sapiens [24]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [25], [26]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [27]
Glutathione reductase (GSR) DME Info Homo sapiens [28]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [29], [30]
Heparanase (HPSE) DME Info Homo sapiens [31], [32]
NADH-ubiquinone oxidoreductase 49 kDa (NDUFS2) DME Info Homo sapiens [31]
NADH-ubiquinone oxidoreductase 30 kDa (NDUFS3) DME Info Homo sapiens [33]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [34]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [31]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [31]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [35]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [36], [37]
Uracil phosphoribosyltransferase (UPRT) DME Info Homo sapiens [38]
References
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2 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics. Bioorg Med Chem. 2007 Oct 15;15(20):6596-607.
3 Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system. Toxicol In Vitro. 2013 Sep;27(6):2005-12.
4 One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease. Pharmacol Res. 2013 Jun;72:69-82.
5 Effects of Andrographis paniculata extract and Andrographolide on hepatic cytochrome P450 mRNA expression and monooxygenase activities after in vivo administration to rats and in vitro in rat and human hepatocyte cultures. Chem Biol Interact. 2009 May 15;179(2-3):247-55.
6 Effect of penicillin-based antibiotics, amoxicillin, ampicillin, and piperacillin, on drug-metabolizing activities of human hepatic cytochromes P450. J Toxicol Sci. 2016 Feb;41(1):143-6.
7 Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett. 2011 Oct 15;3(1):39-42.
8 Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha. Carcinogenesis. 2006 Mar;27(3):656-63.
9 Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol. 2013 Jun 17;26(6):878-95.
10 Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2. Mol Pharmacol. 2007 Mar;71(3):787-98.
11 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
12 Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition. Drug Metab Dispos. 2003 Apr;31(4):439-46.
13 Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. Drug Metab Dispos. 2005 Aug;33(8):1211-9.
14 Trans-resveratrol, but not other natural stilbenes occurring in food, carries the risk of drug-food interaction via inhibition of cytochrome P450 enzymes or interaction with xenosensor receptors. Toxicol Lett. 2019 Jan;300:81-91.
15 Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice. World J Gastroenterol. 2009 Mar 7;15(9):1065-71.
16 Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. Food Chem Toxicol. 2013 May;55:424-33.
17 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
18 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
19 WY 14,643 inhibits human aldose reductase activity. J Enzyme Inhib Med Chem. 2006 Oct;21(5):569-73.
20 Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. Eur J Pharmacol. 2009 Oct 1;619(1-3):1-7.
21 Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer. J Steroid Biochem Mol Biol. 2005 May;95(1-5):129-36.
22 Targeting hepatocellular carcinoma with piperine by radical-mediated mitochondrial pathway of apoptosis: an initro and inivo study. Food Chem Toxicol. 2017 Jul;105:106-118.
23 The inducibility of human cytochrome P450 1A by environmental-relevant xenobiotics in the human hepatoma derived cell line HepG2. Environ Toxicol Pharmacol. 2009 Nov;28(3):370-8.
24 The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11.
25 PPARalpha activation potentiates AhR-induced CYP1A1 expression. Toxicology. 2005 Dec 15;216(2-3):122-8.
26 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
27 PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
28 The effect of the trichloroethylene metabolites trichloroacetate and dichloroacetate on peroxisome proliferation and DNA synthesis in cultured human hepatocytes. Cell Biol Toxicol. 2000;16(4):257-73.
29 Clinical assessment of effects of botanical supplementation on cytochrome P450 phenotypes in the elderly: St John's wort, garlic oil, Panax ginseng and Ginkgo biloba. Drugs Aging. 2005;22(6):525-39.
30 Effect of St John's wort on the activities of CYP1A2, CYP3A4, CYP2D6, N-acetyltransferase 2, and xanthine oxidase in healthy males and females. Br J Clin Pharmacol. 2004 Apr;57(4):495-9.
31 Expression of the human UGT1 locus in transgenic mice by 4-chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid (WY-14643) and implications on drug metabolism through peroxisome proliferator-activated receptor alpha activation. Drug Metab Dispos. 2007 Mar;35(3):419-27.
32 Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology. 2006 Nov;44(5):1158-70.
33 Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor. Mol Pharmacol. 2005 Apr;67(4):1257-67.
34 Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum. 2002 Feb;46(2):494-506.
35 Activation of the constitutive androstane receptor by monophthalates. Chem Res Toxicol. 2016 Oct 17;29(10):1651-1661.
36 Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR). Toxicol Lett. 2011 Apr 25;202(2):148-54.
37 Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. Metabolism. 2005 Feb;54(2):142-50.
38 Hop (Humulus lupulus L.) extract and 6-prenylnaringenin induce P450 1A1 catalyzed estrogen 2-hydroxylation. Chem Res Toxicol. 2016 Jul 18;29(7):1142-50.

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