| General Information of Drug-Metabolizing Enzyme (DME ID: DME0140) |
| DME Name |
Uridine phosphorylase 2 (UPP2), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.4.2.3 (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferases
Pentosyltransferase
EC: 2.4.2.3
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Interactions between Xenobiotics and DME (XEOTIC)
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| Pharmaceutical Agent(s) |
|---|
| Approved/Marketed Drug |
Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
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| Acetaminophen |
Click to Show/Hide the Detail |
Inhibition |
| XEOTIC ID |
XEO00217
XEOTIC Info
|
Gene Form |
mRNA |
| Classification |
Drug Approved by US FDA |
| DME Modulation |
Acetaminophen inhibits the expression of DME UPP2 |
[1] |
| Obeticholic acid |
Click to Show/Hide the Detail |
Induction |
| XEOTIC ID |
XEO00165
XEOTIC Info
|
Gene Form |
mRNA |
| Classification |
Drug Approved by US FDA |
| DME Modulation |
Obeticholic acid up-regulates the expression of DME UPP2 |
[2] |
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| References |
| 1 |
Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
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| 2 |
The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells. Korean J Intern Med. 2015 Nov;30(6):873-83.
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