Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00165)
Xenobiotics Name
Obeticholic acid
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
447715
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [1]
Steroid 21-hydroxylase (CYP21A2) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [4]
Cytochrome P450 3A43 (CYP3A43) DME Info Homo sapiens [5]
Cytochrome P450 3A5 (CYP3A5) DME Info Homo sapiens [6]
Leukotriene B4 omega-hydroxylase (CYP4F3) DME Info Homo sapiens [7]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [8]
Keto-steroid reductase (HSD17B7) DME Info Homo sapiens [1]
Mevalonate pyrophosphate decarboxylase (MPD) DME Info Homo sapiens [9]
UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info Homo sapiens [10]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [8]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info Homo sapiens [11], [2]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info Homo sapiens [2]
DME(s) Induced by This Xenobiotics
Cytochrome P450 2A6 (CYP2A6) DME Info Homo sapiens [12]
Vitamin D 25-hydroxylase (CYP2R1) DME Info Homo sapiens [13]
Glutathione reductase (GSR) DME Info Homo sapiens [13]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [14]
UDP-glucuronosyltransferase 2B15 (UGT2B15) DME Info Homo sapiens [15]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [16]
Uridine phosphorylase 2 (UPP2) DME Info Homo sapiens [16]
Xanthine dehydrogenase/oxidase (XDH) DME Info Homo sapiens [15]
References
1 Interaction of buprenorphine and its metabolite norbuprenorphine with cytochromes p450 in vitro. Drug Metab Dispos. 2003 Jun;31(6):768-72.
2 An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicol In Vitro. 2014 Mar;28(2):231-9.
3 Effects of nitroglycerin and dexamethasone on nitric oxide and endothelin derived from alveolar macrophages in patients with mild and middle asthma. Hunan Yi Ke Da Xue Xue Bao. 2000 Aug 28;25(4):363-6.
4 Proline analogue of nitrosourea as a new cytotoxic prodrug. Arch Pharm (Weinheim). 2009 Nov;342(11):632-9.
5 Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors. Gut. 2000 Dec;47(6):771-8.
6 Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. Eur J Pharmacol. 2007 Sep 24;571(1):44-50.
7 Copper deficiency myelopathy and subacute combined degeneration of the cord - why is the phenotype so similar? Med Hypotheses. 2008 Aug;71(2):229-36.
8 Initro metabolism of N'-nitrosonornicotine catalyzed by cytochrome P450 2A13 and its inhibition by nicotine, N'-nitrosoanatabine and N'-nitrosoanabasine. Chem Biol Interact. 2016 Dec 25;260:263-269.
9 Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
10 Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine. Toxicol Lett. 2016 Jan 22;243:48-55.
11 Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis. Drug Metab Dispos. 2005 Nov;33(11):1637-47.
12 Differential expression of pro-inflammatory and oxidative stress mediators induced by nitrogen dioxide and ozone in primary human bronchial epithelial cells. Inhal Toxicol. 2016 Jul;28(8):374-82.
13 Characteristics of nobiletin-mediated alteration of gene expression in cultured cell lines. Biochem Biophys Res Commun. 2013 Feb 15;431(3):530-4.
14 Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells. Food Chem Toxicol. 2012 Sep;50(9):3320-8.
15 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
16 The effects of nonyl phenoxypolyethoxyl ethanol on cell damage pathway gene expression in SK-NSH cells. Korean J Intern Med. 2015 Nov;30(6):873-83.

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