Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1042)
DME Name Beta-glucuronidase (uidA), Lactobacillus sakei DME Info
UniProt ID
A0A2A5L2J1_LACRH
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Lactobacillus sakei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus sakei
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        8 Xenobiotics
                              Bacteriocin lactocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03775   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lactocyclicin Q inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 0.015 microM) [1], [2]
                              Bacteriocin leucocin N Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03854   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin N inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 1.30 microM) [3]
                              Bacteriocin leucocin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03855   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin leucocin Q inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 1.04 microM) [3]
                              Lantibiotic carnocin-UI49 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03803   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lantibiotic carnocin-UI49 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei [4]
                              Leucocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03857   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leucocyclicin Q inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 0.038 microM) [2]
                              Pediocin PA-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04501   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pediocin PA-1 inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei [5], [6]
                              Plantaricin E Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04616   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin E inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 0.004 microM) [7], [8]
                              Plantaricin F Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04617   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Plantaricin F inhibits the drug-metabolizing activity of Beta-glucuronidase (uidA) from Lactobacillus sakei (MIC = 0.004 microM) [8], [9]
References
1 Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus spstrain QU 12. Appl Environ Microbiol. 2009 Mar;75(6):1552-8.
2 Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 2011 Nov;77(22):8164-70.
3 Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15. J Appl Microbiol. 2010 Jul;109(1):282-91.
4 Purification and characterization of a new bacteriocin isolated from a Carnobacterium sp. Appl Environ Microbiol. 1992 May;58(5):1417-22.
5 Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and bacteriocin from Pediococcus acidilactici PAC1.0. Appl Environ Microbiol. 1992 Aug;58(8):2360-7.
6 Purification and primary structure of pediocin PA-1 produced by Pediococcus acidilactici PAC-1.0. Arch Biochem Biophys. 1992 May 15;295(1):5-12.
7 The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr-like regulatory system. Appl Environ Microbiol. 1994 Jan;60(1):160-6.
8 Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin plantaricin EF. Biochim Biophys Acta. 2008 Nov;1784(11):1711-9.
9 Antagonistic activity of Lactobacillus plantarum C11: two new two-peptide bacteriocins, plantaricins EF and JK, and the induction factor plantaricin A. Appl Environ Microbiol. 1998 Jun;64(6):2269-72.

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