Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1069)
DME Name Nicotinate dehydrogenase (nicA), Pseudomonas putida DME Info
UniProt ID
NICA_PSEPK
EC Number    EC: 1.17.2.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
MCD acceptor oxidoreductase
EC: 1.17.2.1
Lineage    Species: Pseudomonas putida     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas putida
Subspecies: Pseudomonas putida S16
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      23 Xenobiotics
                              Buforin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02649   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Buforin-1 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 4 ug/ml) [1], [2]
                              Buforin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02650   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Buforin-2 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 2 ug/ml) [1], [2]
                              Chrysophsin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02839   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Chrysophsin-1 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 40 microM) [3]
                              Chrysophsin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02842   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Chrysophsin-3 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 40 microM) [3]
                              Gaegurin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03436   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-1 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [4]
                              Gaegurin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03437   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-2 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [4]
                              Gaegurin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03438   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-3 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [4]
                              Gaegurin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03439   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-4 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 100 ug/ml) [5]
                              Gaegurin-5 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03440   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-5 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [4]
                              Gaegurin-6 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03441   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Gaegurin-6 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [4]
                              GGN4 analogue peptide D16W Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03052   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation GGN4 analogue peptide D16W inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 100 ug/ml) [6]
                              KCM12 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03706   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation KCM12 peptide inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [7]
                              KCM21 peptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03707   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation KCM21 peptide inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [7]
                              Lumbrican Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03971   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lumbrican inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [8]
                              Magainin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03985   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Magainin-2 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 10 ug/ml) [9], [10]
                              Misgurin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04117   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Misgurin inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [11]
                              Shepherin I Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04931   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Shepherin I inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [12]
                              shepherin II Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04932   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation shepherin II inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [12]
                              Tigerinin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05144   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tigerinin-1 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 40 ug/ml) [13]
                              Tigerinin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05145   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tigerinin-2 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 50 ug/ml) [13]
                              Tigerinin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05146   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tigerinin-3 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 40 ug/ml) [13]
                              Tigerinin-4 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05147   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tigerinin-4 inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 60 ug/ml) [13]
                              V. philippinarum beta defensin VpBD Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05260   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation V. philippinarum beta defensin VpBD inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida (MIC = 1.64-3.28 microM) [14]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Terpinene-4-ol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05111   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Terpinene-4-ol inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [15]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Burdock leaf ethanolic extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03349   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Burdock leaf ethanolic extract inhibits the drug-metabolizing activity of Nicotinate dehydrogenase (nicA) from Pseudomonas putida [16]
References
1 A novel antimicrobial peptide from Bufo bufo gargarizans. Biochem Biophys Res Commun. 1996 Jan 5;218(1):408-13.
2 Solution structure of an antimicrobial peptide buforin II. FEBS Lett. 1996 Nov 25;398(1):87-90.
3 Purification and characterization of three isoforms of chrysophsin, a novel antimicrobial peptide in the gills of the red sea bream, Chrysophrys major. Eur J Biochem. 2003 Feb;270(4):675-86.
4 Antimicrobial peptides from the skin of a Korean frog, Rana rugosa. Biochem Biophys Res Commun. 1994 Nov 30;205(1):948-54.
5 Solution structure and membrane interaction mode of an antimicrobial peptide gaegurin 4. Biochem Biophys Res Commun. 2007 Jan 19;352(3):592-7.
6 Effects of a tryptophanyl substitution on the structure and antimicrobial activity of C-terminally truncated gaegurin 4. Eur J Biochem. 2002 Sep;269(17):4367-74.
7 Identification of novel bioactive hexapeptides against phytopathogenic bacteria through rapid screening of a synthetic combinatorial library. J Microbiol Biotechnol. 2009 Aug;19(8):792-802.
8 Lumbricin I, a novel proline-rich antimicrobial peptide from the earthworm: purification, cDNA cloning and molecular characterization. Biochim Biophys Acta. 1998 Oct 22;1408(1):67-76.
9 Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc Natl Acad Sci U S A. 1987 Aug;84(15):5449-53.
10 Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR. 1997 Feb;9(2):127-35.
11 A novel antimicrobial peptide from the loach, Misgurnus anguillicaudatus. FEBS Lett. 1997 Jul 14;411(2-3):173-8.
12 Characterization and cDNA cloning of two glycine- and histidine-rich antimicrobial peptides from the roots of shepherd's purse, Capsella bursa-pastoris. Plant Mol Biol. 2000 Sep;44(2):187-97.
13 Tigerinins: novel antimicrobial peptides from the Indian frog Rana tigerina. J Biol Chem. 2001 Jan 26;276(4):2701-7.
14 Molecular characterization of a novel big defensin from clam Venerupis philippinarum. PLoS One. 2010 Oct 20;5(10):e13480.
15 Anti-biofilm forming and anti-quorum sensing activity of selected essential oils and their main components on food-related micro-organisms. J Appl Microbiol. 2013 Oct;115(4):933-42.
16 The effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors of Pseudomonas aeruginosa. J Appl Microbiol. 2017 Mar;122(3):615-624.

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