Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1080)
DME Name Azoreductase (azoR), Streptococcus salivarius DME Info
UniProt ID
A0A074IU04_STRSL
EC Number    EC: 1.7.1.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Cytochrome acceptor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.7.1.6
Lineage    Species: Streptococcus salivarius     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus salivarius
Subspecies: Streptococcus salivarius K12
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bacteriocin lactocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03775   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lactocyclicin Q inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus salivarius (MIC = 22.9 microM) [1], [2]
                              Leucocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03857   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leucocyclicin Q inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus salivarius (MIC = 2.405 microM) [2]
                              Mutacin-1140 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04155   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin-1140 inhibits the drug-metabolizing activity of Azoreductase (azoR) from Streptococcus salivarius [3]
References
1 Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus spstrain QU 12. Appl Environ Microbiol. 2009 Mar;75(6):1552-8.
2 Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 2011 Nov;77(22):8164-70.
3 Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics. Eur J Biochem. 2000 Dec;267(23):6810-6.

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