Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1088)
DME Name Hydroxybenzoate 3-monooxygenase (pobA), Pseudomonas fluorescens DME Info
UniProt ID
PHHY_PSEFL
EC Number    EC: 1.14.13.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
NADH/NADPH donor oxidoreductase
EC: 1.14.13.2
Lineage    Species: Pseudomonas fluorescens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Pseudomonadaceae
Genus: Pseudomonas
Species: Pseudomonas fluorescens
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      16 Xenobiotics
                              Alliumin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02161   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Alliumin inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [1]
                              Antibacterial napin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02237   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial napin inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 66 microM) [2]
                              Antibacterial protein 27kDa Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01927   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Antibacterial protein 27kDa inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 10 ug/ml) [3]
                              Brevinin-1LT1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02532   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1LT1 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 100 microM) [4]
                              CNBr-cleaved lactoferricin 1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02895   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CNBr-cleaved lactoferricin 1 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 50 microM) [5]
                              CNBr-cleaved lactoferricin 2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02896   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation CNBr-cleaved lactoferricin 2 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC > 100 microM) [5]
                              Enterocin AS-48 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03251   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin AS-48 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [6]
                              Fungus ribonuclease Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02301   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Fungus ribonuclease inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [7]
                              Lactoferricin B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03776   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lactoferricin B inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 10 microM) [8]
                              Lebocin-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03846   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lebocin-1/2 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [9], [10]
                              Lebocin-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03847   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lebocin-3 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [9], [11]
                              M-zodatoxin-Lt8a Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04184   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation M-zodatoxin-Lt8a inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 3.8 microM) [12]
                              M-zodatoxin-Lt8c Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04185   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation M-zodatoxin-Lt8c inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [12]
                              Moricin-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04128   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Moricin-1 inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 0.53 microM) [13], [14]
                              Napin-like polypeptide Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04235   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Napin-like polypeptide inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [15]
                              Temporin-LTc Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05096   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Temporin-LTc inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens (MIC = 100 ug/ml) [16]
      Natural Product(s), Extract(s) or Medicine(s)
                  Bacterial Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Bacillus licheniformis SP1 culture supernatant Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02990   XEOTIC Info Gene Form Protein
                                 Classification Bacterial Extract
                                 DME Modulation Bacillus licheniformis SP1 culture supernatant inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [17]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Calcium chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00837   XEOTIC Info Gene Form Protein
                                 Classification Drug Marketed but not Approved by US FDA
                                 DME Modulation Calcium chloride inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [18]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Sodium chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04963   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Sodium chloride inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [18]
                              Sodium sulfate Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04964   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Sodium sulfate inhibits the drug-metabolizing activity of Hydroxybenzoate 3-monooxygenase (pobA) from Pseudomonas fluorescens [18]
References
1 Isolation of alliumin, a novel protein with antimicrobial and antiproliferative activities from multiple-cloved garlic bulbs. Peptides. 2005 Feb;26(2):177-83.
2 A napin-like polypeptide from dwarf Chinese white cabbage seeds with translation-inhibitory, trypsin-inhibitory, and antibacterial activities. Peptides. 2004 Feb;25(2):171-6.
3 Characterization and ion channel activities of novel antibacterial proteins from the skin mucosa of carp (Cyprinus carpio). Eur J Biochem. 1996 Aug 15;240(1):143-9.
4 Isolation, characterization and molecular cloning of new antimicrobial peptides belonging to the brevinin-1 and temporin families from the skin of Hylarana latouchii (Anura: Ranidae). Biochimie. 2009 Apr;91(4):540-7.
5 Antibacterial activity in bovine lactoferrin-derived peptides. Antimicrob Agents Chemother. 1997 Jan;41(1):54-9.
6 Bactericidal and bacteriolytic action of peptide antibiotic AS-48 against gram-positive and gram-negative bacteria and other organisms. Res Microbiol. 1989 Jan;140(1):57-68.
7 A ribonuclease with antimicrobial, antimitogenic and antiproliferative activities from the edible mushroom Pleurotus sajor-caju. Peptides. 2004 Jan;25(1):11-7.
8 Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry. 1998 Mar 24;37(12):4288-98.
9 A novel antibacterial peptide family isolated from the silkworm, Bombyx mori. Biochem J. 1995 Sep 1;310 ( Pt 2):651-6.
10 cDNA cloning and gene expression of lebocin, a novel member of antibacterial peptides from the silkworm, Bombyx mori. Biochem Biophys Res Commun. 1995 Sep 5;214(1):271-8.
11 A novel member of lebocin gene family from the silkworm, Bombyx mori. Biochem Biophys Res Commun. 1997 Sep 29;238(3):769-74.
12 Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem J. 2008 May 1;411(3):687-96.
13 Moricin, a novel type of antibacterial peptide isolated from the silkworm, Bombyx mori. J Biol Chem. 1995 Dec 15;270(50):29923-7.
14 Solution structure of moricin, an antibacterial peptide, isolated from the silkworm Bombyx mori. FEBS Lett. 2002 May 8;518(1-3):33-8.
15 A napin-like polypeptide with translation-inhibitory, trypsin-inhibitory, antiproliferative and antibacterial activities from kale seeds. J Pept Res. 2004 Nov;64(5):202-8.
16 The novel antimicrobial peptides from skin of Chinese broad-folded frog, Hylarana latouchii (Anura:Ranidae). Peptides. 2009 Feb;30(2):273-82.
17 Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of Bacillus licheniformis. Microb Cell Fact. 2011 Sep 27;10:74.
18 Response of microbial adhesives and biofilm matrix polymers to chemical treatments as determined by interference reflection microscopy and light section microscopy. Appl Environ Microbiol. 1989 Nov;55(11):2827-31.

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