Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1090)
DME Name Aminoglycoside phosphotransferase (aph-Ib), Campylobacter jejuni DME Info
UniProt ID
A0A075C7U3_CAMJU
EC Number    EC: 2.7.1.190     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.190
Lineage    Species: Campylobacter jejuni     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species: Campylobacter jejuni
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Bacteriocin E50-52 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02376   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin E50-52 inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni (MIC = 0.025-6.4 ug/ml) [1]
                              Bacteriocin L-1077 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02378   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin L-1077 inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni (MIC = 0.09 ug/ml) [2]
                              Bacteriocin OR-7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02381   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin OR-7 inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [3]
                              Enterocin E-760 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03253   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin E-760 inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni (MIC = 0.1 ug/ml) [4]
                              Mutacin II mutacin H-29B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04156   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin II mutacin H-29B inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [5]
      Health or Environmental Toxicant(s)
                  Acute Toxic Substance Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Evodiamine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03369   XEOTIC Info Gene Form Protein
                                 Classification Acute Toxic Substance
                                 DME Modulation Evodiamine inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [6]
      Natural Product(s), Extract(s) or Medicine(s)
                  Natural Product Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Rutecarpine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01462   XEOTIC Info Gene Form Protein
                                 Classification Natural Product
                                 DME Modulation Rutecarpine inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [6]
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Euodia ruticarpa ethanol solution extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03407   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Euodia ruticarpa ethanol solution extract inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [6]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Chloramphenicol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00220   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Chloramphenicol inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [7]
                  Investigative Agent Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              Glucose Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03489   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Glucose inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [7]
                              Sucrose Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05010   XEOTIC Info Gene Form Protein
                                 Classification Investigative Agent
                                 DME Modulation Sucrose inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [7]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Sodium chloride Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04963   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation Sodium chloride inhibits the drug-metabolizing activity of Aminoglycoside phosphotransferase (aph-Ib) from Campylobacter jejuni [7]
References
1 Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. J Agric Food Chem. 2008 Mar 26;56(6):1942-8.
2 Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum. Appl Environ Microbiol. 2011 Apr;77(8):2749-54.
3 Isolation of a Lactobacillus salivarius strain and purification of its bacteriocin, which is inhibitory to Campylobacter jejuni in the chicken gastrointestinal system. Antimicrob Agents Chemother. 2006 Sep;50(9):3111-6.
4 Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2008 Mar;52(3):1094-100.
5 Biochemical structural analysis of the lantibiotic mutacin II. J Biol Chem. 2000 May 26;275(21):15845-50.
6 Attenuation of adhesion, biofilm formation and quorum sensing of Campylobacter jejuni by Euodia ruticarpa. Phytother Res. 2016 Sep;30(9):1527-32.
7 Characterization of campylobacter jejuni biofilms under defined growth conditions. Appl Environ Microbiol. 2007 Mar;73(6):1908-13.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.