Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1100)
DME Name Arylamine N-acetyltransferase (NAT), Shigella flexneri DME Info
UniProt ID
A0A1C3HAL9_SERMA
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Shigella flexneri     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella flexneri
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      12 Xenobiotics
                              Apidaecin-1A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02304   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-1A inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 0.1 ug/ml) [1]
                              Apidaecin-1B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02305   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-1B inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 0.1 ug/ml) [1], [2]
                              Apidaecin-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02306   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Apidaecin-2 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 0.1 ug/ml) [1]
                              Astacidin 2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02332   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Astacidin 2 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 0.98 ug/ml) [3]
                              GAPDH-related antimicrobial YFGAP Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05308   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation GAPDH-related antimicrobial YFGAP inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 2.0 ug/ml) [4]
                              Microcin 7 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04111   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin 7 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri [5]
                              Microcin J25 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04113   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin J25 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri [6]
                              Microcin L Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04114   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Microcin L inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri [7], [8]
                              Piscidin Pis-1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04612   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-1 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 2.5-5 microM) [9]
                              Piscidin Pis-2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04613   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Piscidin Pis-2 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri (MIC = 2.5-5 microM) [10]
                              Subpeptin JM4-B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05005   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Subpeptin JM4-B inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri [11]
                              Thuricin-S Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05139   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Thuricin-S inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Shigella flexneri [12]
References
1 Apidaecins: antibacterial peptides from honeybees. EMBO J. 1989 Aug;8(8):2387-91.
2 Isolation and characterization of abaecin, a major antibacterial response peptide in the honeybee (Apis mellifera). Eur J Biochem. 1990 Jan 26;187(2):381-6.
3 Antibacterial peptides in hemocytes and hematopoietic tissue from freshwater crayfish Pacifastacus leniusculus: characterization and expression pattern. Dev Comp Immunol. 2007;31(5):441-55.
4 Purification and characterization of YFGAP, a GAPDH-related novel antimicrobial peptide, from the skin of yellowfin tuna, Thunnus albacares. Fish Shellfish Immunol. 2012 Oct;33(4):743-52.
5 Structure and mode of action of microcin 7, an antibacterial peptide produced by Escherichia coli. Antimicrob Agents Chemother. 1985 May;27(5):791-7.
6 Microcin J25 has a threaded sidechain-to-backbone ring structure and not a head-to-tail cyclized backbone. J Am Chem Soc. 2003 Oct 15;125(41):12464-74.
7 Genetic analysis and complete primary structure of microcin L. Antimicrob Agents Chemother. 2004 Feb;48(2):505-13.
8 Wild-type Escherichia coli producing microcins B17, D93, J25, and L; cloning of genes for microcin L production and immunity. Can J Microbiol. 2003 May;49(5):357-61.
9 Peptide antibiotics in mast cells of fish. Nature. 2001 Nov 15;414(6861):268-9.
10 Discovery and characterization of two isoforms of moronecidin, a novel antimicrobial peptide from hybrid striped bass. J Biol Chem. 2002 Feb 15;277(7):5030-9.
11 Purification and characterization of two novel antimicrobial peptides Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4. Curr Microbiol. 2005 Nov;51(5):292-6.
12 Purification and partial amino acid sequence of thuricin S, a new anti-Listeria bacteriocin from Bacillus thuringiensis. Can J Microbiol. 2007 Feb;53(2):284-90.

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