Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1102)
DME Name Arylamine N-acetyltransferase (NAT), Morganella morganii DME Info
UniProt ID
A0A0A2RAD0_MORMO
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Morganella morganii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Morganella
Species: Morganella morganii
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Bacteriocin E50-52 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02376   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin E50-52 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii [1]
                              Bacteriocin L-1077 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02378   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin L-1077 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii (MIC = 0.38 ug/ml) [2]
                              Enterocin E-760 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03253   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin E-760 inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii [3]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        3 Xenobiotics
                              Amikacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00122   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Amikacin inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii [4]
                              Ceftazidime Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00237   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ceftazidime inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii [4]
                              Ciprofloxacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00349   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Ciprofloxacin inhibits the drug-metabolizing activity of Arylamine N-acetyltransferase (NAT) from Morganella morganii [4]
References
1 Diverse antimicrobial killing by Enterococcus faecium E 50-52 bacteriocin. J Agric Food Chem. 2008 Mar 26;56(6):1942-8.
2 Isolation of Lactobacillus salivarius 1077 (NRRL B-50053) and characterization of its bacteriocin, including the antimicrobial activity spectrum. Appl Environ Microbiol. 2011 Apr;77(8):2749-54.
3 Isolation and purification of enterocin E-760 with broad antimicrobial activity against gram-positive and gram-negative bacteria. Antimicrob Agents Chemother. 2008 Mar;52(3):1094-100.
4 Effect of ceftazidime, amikacin and ciprofloxacin on biofilm formation by some enterobacterial clinical isolates. Chemotherapy. 2004 Nov;50(5):255-9.

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