Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1416)
DME Name	Unclear metabolic mechanism (DME-unclear), Enterobacter cancerogenus	DME Info
Lineage	Species: Enterobacter cancerogenus (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Enterobacterales Family: Enterobacteriaceae Genus: Enterobacter Species: Enterobacter cancerogenus Subspecies: Enterobacter cancerogenus ATCC 35316
Interactome

Interactions between Xenobiotics and DME (XEOTIC)
Pharmaceutical Agent(s)
Drug in Phase 3 Clinical Trial		Click to Show/Hide the Full List of Xenobiotics: 2 Xenobiotics
Curcumin		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00683 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Curcumin inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Enterobacter cancerogenus				[1]
Epigallocatechin gallate		Click to Show/Hide the Detail			Inhibition
XEOTIC ID	XEO00613 XEOTIC Info		Gene Form	Protein
Classification	Highest Clinical Status: Phase 3
DME Modulation	Epigallocatechin gallate inhibits the drug-metabolizing activity of Unclear enzyme (DME-unclear) from Enterobacter cancerogenus				[1]

References
1	Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.

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