Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00613)
Xenobiotics Name
Epigallocatechin gallate
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 3 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
65064
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Ampc beta-lactamase (ampC) DME Info Burkholderia cenocepacia [1]
AmpC beta-lactamase (ampC) DME Info Burkholderia multivorans [1]
Beta-lactamase (blaB) DME Info Citrobacter freundii [2]
Beta-lactamase (blaB) DME Info Serratia marcescens [2]
Carbapenemase (cphA) DME Info Aeromonas hydrophila [2]
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [3]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [4]
Unclear metabolic mechanism (DME-unclear) DME Info Citrobacter freundii [2]
Unclear metabolic mechanism (DME-unclear) DME Info Enterobacter cancerogenus [2]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [5]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [6]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [6]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [6]
Metallothionein-2A (MT2A) DME Info Homo sapiens [7]
Glutamate racemase (MurI) DME Info Streptococcus mutans [5]
Arylamine N-acetyltransferase (NAT) DME Info Serratia marcescens [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [8]
Arylamine N-acetyltransferase (NAT) DME Info Citrobacter freundii [2]
Beta-lactamase (blaB) DME Info Burkholderia multivorans [1]
Beta-lactamase (blaB) DME Info Burkholderia cenocepacia [1]
Prostaglandin G/H synthase 1 (COX-1) DME Info Homo sapiens [3]
Steroid 5-alpha-reductase 2 (SRD5A2) DME Info Homo sapiens [9]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [10]
Glutathione reductase (GSR) DME Info Homo sapiens [10]
Nitric oxide synthase endothelial (NOS3) DME Info Homo sapiens [11], [9]
Choline phosphatase 1 (PLD1) DME Info Homo sapiens [12]
NADPH-cytochrome P450 reductase (CPR) DME Info Homo sapiens [13]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [14]
References
1 Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia. Res Microbiol. 2009 Mar;160(2):144-51.
2 Combined effects of curcumin and (-)-epigallocatechin gallate on inhibition of N-acylhomoserine lactone-mediated biofilm formation in wastewater bacteria from membrane bioreactor. J Microbiol Biotechnol. 2015 Nov;25(11):1908-19.
3 Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact. 2010 Dec 5;188(3):659-67.
4 Binding of natural and synthetic polyphenols to human dihydrofolate reductase. Int J Mol Sci. 2009 Dec 18;10(12):5398-410.
5 Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes. Arch Oral Biol. 2012 Jun;57(6):678-83.
6 Impact of epigallocatechin gallate on gene expression profiles of human hepatocellular carcinoma cell lines BEL7404/ADM and BEL7402/5-FU. Ai Zheng. 2008 Oct;27(10):1056-64.
7 Dietary catechins and procyanidins modulate zinc homeostasis in human HepG2 cells. J Nutr Biochem. 2011 Feb;22(2):153-63.
8 Epigallocatechin gallate inhibits biofilm formation by ocular staphylococcal isolates. Antimicrob Agents Chemother. 2005 Oct;49(10):4339-43.
9 Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010.
10 Green tea catechins alone or in combination alter functional parameters of human neutrophils via suppressing the activation of TLR-4/NFB p65 signal pathway. Toxicol In Vitro. 2015 Oct;29(7):1766-78.
11 Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br J Nutr. 2010 May;103(10):1398-403.
12 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
13 Activity of NADPH-cytochrome P-450 reductase of the human heart, liver and lungs in the presence of (-)-epigallocatechin gallate, quercetin and resveratrol: an in vitro study. Basic Clin Pharmacol Toxicol. 2005 Aug;97(2):74-9.
14 Phospholipase D isozymes mediate epigallocatechin gallate-induced cyclooxygenase-2 expression in astrocyte cells. J Biol Chem. 2004 Sep 10;279(37):38125-33.

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