Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1549)
DME Name Cytochrome P450 125A3 (cyp125), Mycolicibacterium smegmatis DME Info
UniProt ID
CP125_MYCS2
EC Number    EC: 1.14.15.29     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.29
Lineage    Species: Mycolicibacterium smegmatis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycolicibacterium
Species: Mycolicibacterium smegmatis
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:        5 Xenobiotics
                              Lariatins A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03807   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lariatins A inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [1]
                              Lariatins B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03808   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Lariatins B inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [1]
                              Mutacin II mutacin H-29B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04156   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mutacin II mutacin H-29B inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [2]
                              Sapecin defensin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04904   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sapecin defensin inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis (MIC = 78 ug/ml) [3], [4]
                              Sarcotoxin-1D Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04909   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Sarcotoxin-1D inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [3]
      Natural Product(s), Extract(s) or Medicine(s)
                  Plant Extract Click to Show/Hide the Full List of Xenobiotics:        4 Xenobiotics
                              Parinari curatellifolia DCM extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03084   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Parinari curatellifolia DCM extract inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [5]
                              Parinari curatellifolia ethyl acetate extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03353   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Parinari curatellifolia ethyl acetate extract inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [5]
                              Parinari curatellifolia hexane extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03553   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Parinari curatellifolia hexane extract inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [5]
                              Parinari curatellifolia methanol extract Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04085   XEOTIC Info Gene Form Protein
                                 Classification Plant Extract
                                 DME Modulation Parinari curatellifolia methanol extract inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [5]
      Pharmaceutical Agent(s)
                  Approved/Marketed Drug Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Acetylcysteine Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO00110   XEOTIC Info Gene Form Protein
                                 Classification Drug Approved by US FDA
                                 DME Modulation Acetylcysteine inhibits the drug-metabolizing activity of Cytochrome P450 125A3 (cyp125) from Mycolicibacterium smegmatis [6]
References
1 Lariatins, antimycobacterial peptides produced by Rhodococcus spK01-B0171, have a lasso structure. J Am Chem Soc. 2006 Jun 14;128(23):7486-91.
2 Mutacin H-29B is identical to mutacin II (J-T8). BMC Microbiol. 2006 Apr 20;6:36.
3 Purification of three antibacterial proteins from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina. J Biol Chem. 1988 Nov 15;263(32):17112-6.
4 Determination of the disulfide array in sapecin, an antibacterial peptide of Sarcophaga peregrina (flesh fly). J Biochem. 1990 Apr;107(4):514-8.
5 Inhibition of biofilm formation in Mycobacterium smegmatis by Parinari curatellifolia leaf extracts. BMC Complement Altern Med. 2017 May 30;17(1):285.
6 N-acetylcysteine inhibits growth, adhesion and biofilm formation of Gram-positive skin pathogens. Microb Pathog. 2017 Apr;105:145-152.

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