Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1643)
DME Name Beta-lactamase (blaB), Chromobacterium violaceum DME Info
UniProt ID
A0A3S4HKA9_CHRVL
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Chromobacterium violaceum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Neisseriales
Family: Chromobacteriaceae
Genus: Chromobacterium
Species: Chromobacterium violaceum
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Pharmaceutical Agent(s)
                  Drug in Phase 1 Clinical Trial Click to Show/Hide the Full List of Xenobiotics:        1 Xenobiotics
                              Carvacrol Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01237   XEOTIC Info Gene Form Protein
                                 Classification Highest Clinical Status: Phase 1
                                 DME Modulation Carvacrol inhibits the drug-metabolizing activity of Beta-lactamase (blaB) from Chromobacterium violaceum [1]
References
1 The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. PLoS One. 2014 Apr 1;9(4):e93414.

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