Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO01237)
Xenobiotics Name
Carvacrol
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Drug in Phase 1 Clinical Trial
Structure
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3D MOL 2D MOL
PubChem CID
10364
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aminoglycoside adenylyltransferase (aadA1a) DME Info Salmonella enterica [1]
Beta-lactamase (blaB) DME Info Chromobacterium violaceum [1]
Azoreductase (azoR) DME Info Escherichia coli [2]
L,D-carboxypeptidase A (ldcA) DME Info Escherichia coli [2]
Beta-lactamase (blaB) DME Info Escherichia coli [2]
New delhi metallo-beta-lactamase NDM-1 (blaNDM) DME Info Salmonella enterica [1]
Chloramphenicolase (chlR) DME Info Escherichia coli [2]
Glycoside hydrolase (cscA) DME Info Escherichia coli [2]
NADPH-dependent curcumin reductase (curA) DME Info Escherichia coli [2]
Unclear metabolic mechanism (DME-unclear) DME Info Escherichia coli [2]
Unclear metabolic mechanism (DME-unclear) DME Info Streptococcus mutans [3]
Glutamate decarboxylase (gadB) DME Info Escherichia coli [2]
D-Lactate dehydrogenase (ldhA) DME Info Escherichia coli [2]
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1]
Homoserine-O-transsuccinylase (metAA) DME Info Salmonella enterica [1]
Molybdopterin-dependent enzyme (molD) DME Info Escherichia coli [2]
Glutamate racemase (MurI) DME Info Escherichia coli [2]
Glutamate racemase (MurI) DME Info Streptococcus mutans [3]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1]
N-ethylmaleimide reductase (nemA) DME Info Escherichia coli [2]
NADPH-dependent oxidoreductase (nfrA) DME Info Staphylococcus aureus [1]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase A (nfsA) DME Info Salmonella enterica [1]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Escherichia coli [2]
Oxygen-insensitive NADPH nitroreductase B (nfsB) DME Info Salmonella enterica [1]
Arylamine N-acetyltransferase (NAT) DME Info Salmonella enterica [1]
NADH dehydrogenase (nuoE) DME Info Streptomyces griseus [2]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1]
Tyramine oxidase (tynA) DME Info Escherichia coli [2]
Beta-glucuronidase (uidA) DME Info Escherichia coli [2]
Nitroreductase (NTR) DME Info Salmonella enterica [1]
Nitroreductase (NTR) DME Info Salmonella typhimurium [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [4]
References
1 The natural antimicrobial carvacrol inhibits quorum sensing in Chromobacterium violaceum and reduces bacterial biofilm formation at sub-lethal concentrations. PLoS One. 2014 Apr 1;9(4):e93414.
2 Essential oils and eugenols inhibit biofilm formation and the virulence of Escherichia coli O157:H7. Sci Rep. 2016 Nov 3;6:36377.
3 Thymol and carvacrol induce autolysis, stress, growth inhibition and reduce the biofilm formation by Streptococcus mutans. AMB Express. 2017 Dec;7(1):49.
4 Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR. Food Chem Toxicol. 2018 Jan;111:374-384.

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