| General Information of DME (ID: DME0081) |
| DME Name |
Glutathione S-transferase alpha-2 (GSTA2), Homo sapiens
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| Synonyms |
Glutathione S-transferase A2; GST class-alpha member 2; GST-gamma; GST HA subunit 2; GST2; GSTA2; GSTA2-2; GTH2
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| Gene Name |
GSTA2
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 2.5.1.18 (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.18
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Xenobiotics and DME (XEOTIC)  Jump to Detailed Interactome Data  |
Interactions between Host Protein and DME (HOSPPI) Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Sequence |
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
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| Structure |
1AGS
; 2VCT
; 2WJU
; 4ACS
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| Pathway |
Chemical carcinogenesis (hsa05204 ) |
| Drug metabolism - cytochrome P450 (hsa00982 ) |
| Drug metabolism - other enzymes (hsa00983 ) |
| Fluid shear stress and atherosclerosis (hsa05418 ) |
| Glutathione metabolism (hsa00480 ) |
| Hepatocellular carcinoma (hsa05225 ) |
| Metabolic pathways (hsa01100 ) |
| Metabolism of xenobiotics by cytochrome P450 (hsa00980 ) |
| Pathways in cancer (hsa05200 ) |
| Platinum drug resistance (hsa01524 ) |
| Function |
This enzyme conjugates reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
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