General Information of DME (ID: DME0610)
DME Name Glutathione peroxidase 6 (GPX6), Homo sapiens
Synonyms Cellular glutathione peroxidase; 3,3'-telluro-bis(proapne-3,1-diyl)adamantane carboxylate; ADA-Te-OH; ARMEP24; AtGPX1; ATGPX3; c-GPx4; GPX6; GPx-6; GSHPx-6
Gene Name GPX6
UniProt ID
GPX6_HUMAN
Gene ID
257202
EC Number    EC: 1.11.1.9     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Peroxidase
Peroxidase
EC: 1.11.1.9
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Microbiome and DME (MICBIO)                       
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Sequence
MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFA
GKHVLFVNVAAYUGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLK
YVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIR
WNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH
Pathway Amyotrophic lateral sclerosis (ALS) (hsa05014 )
Arachidonic acid metabolism (hsa00590 )
Glutathione metabolism (hsa00480 )
Huntington's disease (hsa05016 )
Metabolic pathways (hsa01100 )
Thyroid hormone synthesis (hsa04918 )
Function This enzyme has glutathione peroxidase activity and peroxidase activity.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 2 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
ANW-43980
Drug Info Phase 2 Parkinsonism ICD11: 8A00 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007253 ANW-43980 Unclear Unclear - Unclear ANW-43980 [1]
References
1 Metabolomics reveals a role for the chromatin-binding protein HMGN5 in glutathione metabolism. PLoS One. 2014 Jan 2;9(1):e84583.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.