Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1005)
DME Name L-arabinose isomerase (araA), Lactobacillus fermentum
Synonyms Isomerase L-arabinose; D-arabinose aldose-ketose-isomerase; araA
Gene Name araA
UniProt ID
D9ILD9_LACFE
EC Number    EC: 5.3.1.4     (Click to Show/Hide the Complete EC Tree)
Isomerase
Intramolecular oxidoreductase
Aldose/ketose isomerase
EC: 5.3.1.4
Lineage    Species: Lactobacillus fermentum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus fermentum
Subspecies: Lactobacillus fermentum CGMCC 2921
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MRKMQDYKFWFVVGSQPLYGPEALAEVEKDARKLVDGLNKGGKLDYPVEFKLVATTADSI
TKFMKEANYNDDVAGVITWMHTFSPAKNWIRGTELLQKPLLHLATQFLNNIPFDSIDMDY
MNLHQSAHGDREYAYINSRLNVPAASVYGWWGDADVQEQIADWQHVAVAYNESFHIKIAR
FGDTMRDVAVTEGDKVAAQIKLGWTVDYYPTNELVAVVNGIAEDEIDAAYKDLEANYDLV
EGDNDHEKYVHNVRYQLREYLGIKKFLDDNGYDAFTDNFQDLEGLEQLPGLAVQLLMIDG
YGFGPEGDFKMAGLTRLLKIAADNKQTALMEDYTLDLRHGHEAIMGSHMLEVDPTLASDK
PRVEVHPLGIGGKDDPARLVFTGAEGKGYDITLSYFDDGYKFIGYPVDCKTPEAEMPKLP
VAKQMWTPEIGLAEGAKQWMKYGGGHHTVLTLALSEEQLEQLARLFKVDFINIK
Structure
4LQL
Function This enzyme catalyzes the conversion of L-arabinose to L-ribulose. It requires a divalent metal ion and binds the closed form of the sugar and catalyses ring opening to generate a form of open-chain conformation that facilitates the isomerization reaction, which proceeds via an ene-diol mechanism. It can also convert D-galactose to D-tagatose with lower efficiency.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Alpha-l-arabinose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Protein purification, crystallization and preliminary X-ray diffraction analysis of L-arabinose isomerase from Lactobacillus fermentum CGMCC2921. Acta Crystallogr F Struct Biol Commun. 2015 Jan 1;71(Pt 1):28-33.

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