Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1008)
DME Name Tripeptidase (pepT), Lactococcus lactis
Synonyms Aminotripeptidase; Tripeptide aminopeptidase; Peptidase T; L9PepTR; pepT
Gene Name pepT
UniProt ID
PEPT_LACLL
EC Number    EC: 3.4.11.4     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Aminopeptidase
EC: 3.4.11.4
Lineage    Species: Lactococcus lactis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Lactococcus
Species: Lactococcus lactis
Subspecies: Lactococcus lactis subsp. lactis (L9)
Subspecies: Lactococcus lactis subsp. hordniae (hT)
Subspecies: Lactococcus lactis subsp. cremoris (L6)
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKYEKLLPRFLEYVKVNTRSDENSTTTPSTQALVEFAHKMGEDMKALGLKDVHYLESNGY
VIGTIPANTDKKVRKIGLLAHLDTADFNAEGVNPQILENYDGESVIKLGDTEFTLDPKDF
PNLKNYKGQTLVHTDGTTLLGSDDKSGVAEIMTLADYLLNINPDFEHGEIRVGFGPDEEI
GVGADKFDVADFDVDFAYTVDGGPLGELQYETFSAAGAVIEFQGKNVHPGTAKNTMVNAL
QLAIDYHNALPEFDRPEKTEGREGFFHLLKLDGTPEEARAQYIIRDHEEGKFNERKALMQ
EIADKMNAELGQNRVKPVIKDQYYNMAQIIEKDMSIIDIAKKAMENLDIVPIIEPIRGGT
DGSKISFMGLPTPNLFAGGENMHGRFEFVSVQTMEKAVDTLLEIIRLNNEVVK
Function This enzyme catalyzes release of the N-terminal residue from a tripeptide.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Glypromate
 Drug Info Phase 4 Epilepsy ICD11: 8A60 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Azetirelin
 Drug Info Investigative Discovery agent ICD: N.A. [2], [3]
References
1 Tripeptidase gene (pepT) of Lactococcus lactis: molecular cloning and nucleotide sequencing of pepT and construction of a chromosomal deletion mutant. J Bacteriol. 1994 May;176(10):2854-61.
2 Metabolism of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue, by intestinal microorganisms. Pharm Res. 1997 Aug;14(8):1004-7.
3 Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. I. Possible factors for the low oral bioavailability in rats. Biol Pharm Bull. 1994 Sep;17(9):1256-61.

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