Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1029)
DME Name Glycerol-3-phosphate dehydrogenase (gpsA), Erysipelothrix rhusiopathiae
Synonyms Dihydroxyacetone-phosphate reductase; GPD-C; GPDH-C; gpsA
Gene Name gpsA
UniProt ID
A0A411LCN0_ERYRH
EC Number    EC: 1.1.1.94     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.94
Lineage    Species: Erysipelothrix rhusiopathiae     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Erysipelotrichia
Order: Erysipelotrichales
Family: Erysipelotrichaceae
Genus: Erysipelothrix
Species: Erysipelothrix rhusiopathiae
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
GHEVMMWGRKLDQVVDVHLYHLNEEFFPGVKLNERLDATQNFEDILDSQIILLAVPTGAV
EEVCIELNAHLSNPVIIINVAKGLHPTTHELLDHVIKRVIDSNKLKGVVSLIGPSHAEEV
VLRKITTINAVSDNPALAEEVQVLFSNDYFRVYTNDDVIGSQYGVAIKNVIALASGIAAG
LDAGDNARAALITRGLTEMQRFGVHMGGQPETYLGLCGVGDLVVTATSVHSRNFQAGMEI
GQKNSAVGFLDHNTKTVEGVFAAKVVYEIAVEEGIDMPITEQIYKIIYEEKR
Function This enzyme shows specificity for the B side of NADPH.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Chloramphenicol
 Drug Info Approved Conjunctivitis ICD11: 9A60 [1], [2]
References
1 Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol. 2008 Jan;45(2):386-94.
2 Dehydrogenase activity of chlornitromycin-resistant variants of Erysipelothrix rhusiopathiae. Izv Mikrobiol Inst (Sofiia). 1969;20:257-62.

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