Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1042)
DME Name Beta-glucuronidase (uidA), Lactobacillus sakei
Synonyms Beta-galactosidase/beta-glucuronidase; Beta-galactosidase BgaB; BGK71_00200; CCE29_06935; FEZ43_12625; NCTC13710_00049; PY91_01090; uidA
Gene Name uidA
UniProt ID
A0A2A5L2J1_LACRH
Gene ID
8420464
EC Number    EC: 3.2.1.31     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.31
Lineage    Species: Lactobacillus sakei     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus sakei
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
METSLLYPVTNDQRTDQKLDGLWQFKFDEAGEGEKSGWETGFHDGVSMPVPASFNDFFTD
KASREYTGDFWYSRNFFVPSAAKGKALFLRFDAVTHRATIFVNGKEIRTHEGGFLPFAAD
ISEAVKYGAENTVVVKGNNELSREALPAGDTITLRNGKKMVRPFFDFYNYSGLNRSVHLL
SLPQERVLDYTTTFALAGNDATVNYTVETNGDAPVTVSLADADGQVVATAQGKQGALQVQ
NAHLWQVRNAYLYTLTIQLGDDTQTPLDTYTDRIGIRTIKISGTDILVNDKPIYLKGFGR
HEDSPFAGRAFDLNVEKKDFALMKWIGANSFRTSHYPYDEQVYKIADEEGFLLTDEVPAV
GFKMAAAAFLGGLNQSFFKGPWLKKLHERHIDQIRDLIKRDKNHPSVLAWSLFNEPDTID
ENAVPYFKQIFDESKDLDPQGRPRTFTLSEDDTIETSKVLDFPDFYMLNRYPGWYHFGGY
QISDGEAGLRDEMDKWQKAGVKKPVVFTEFGADTEAGLHKLPSVMWTEEYQVEVLKMFSR
VFDDYDFIKGEQVWNLADFQTVEGNMRVNGNKKGIFTRDRQPKAAAFFYHDRWNKLPLDY
KAK
Structure
6ECA
Function This enzyme takes part in glucuronoside catabolic process. It catalyzes the hydrolysis of beta-glucuronide containing substrates.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Erythromycin stearate
 Drug Info Approved Acute upper respiratory infection ICD11: CA07 [1], [2]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Chondroitin sulfate
 Drug Info Phase 4 Osteoarthritis ICD11: FA00 [3]
References
1 Identification of Lactobacillus sakei genes induced during meat fermentation and their role in survival and growth. Appl Environ Microbiol. 2007 Apr;73(8):2522-31.
2 Degradation of various insecticides in cooked eggs during in vitro human digestion. Environ Pollut. 2018 Dec;243(Pt A):437-443.
3 DrugBank(Pharmacology-Metabolism):Chondroitin?sulfate

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