Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1045)
DME Name Beta-glucosidase (bglA), Trichophyton interdigitale
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BG; H109_07780
Gene Name bglA
UniProt ID
A0A059IXB8_TRIIM
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Trichophyton interdigitale     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Fungi
Phylum: Ascomycota
Class: Eurotiomycetes
Order: Onygenales
Family: Arthrodermataceae
Genus: Trichophyton
Species: Trichophyton interdigitale
Subspecies: Trichophyton interdigitale NCPF 0335
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MLFRWCPLVALAIASGTAATEQSWESPPYYPSPWTKGEGEWEDAYQKAVSFVSQLTLAEK
VNLTTGVGWMQESCVGQVGSIPRLGFRSLCMQDGPLGIRFGDYVTAFPAGINVAATWSRE
LAYLRGKAMGEEFHGKGADVILGPAIGPIGRAPEGGRNWEGFGPDPVLAGRLVAETIKGM
QKTGVIACAKHFIANEQERFRIAAEAQGYGFDIAESISSNVDDVTMHEIYLWPFADAVKA
GVGSIMCSYNQINNSYGCGNSYTQNKLLKGELGFRGFIMSDWQAHHSGVGSAFAGLDMSM
PGDTLFGTGVSFWGANLTIAVANGTIPEWRVDDMAVRIMAAYYKVGRDKVQVPINFNSWT
TDVEGYQHALVKEGYGVVNQRVNVRDHHARIARRMASDSIVLLKNEGVLPLTGTEQFTAI
IGEDAGPNINGPNSCPDRGCDNGTLAMGWGSGTTNFPYLVTPDDAIQREIVAKGVGNVMS
VLQNGDFKNIQSVAGQANVALVFINSDSGEGYISVDGNEGDRKNLTTWKGGDEMVKQVTS
VCNNTVLVIHSSGPILAGQWHDNPNITAILWAGLPGQESGNALVDVLYGKVNPGGKSPFT
WGRTAEDYGTTILREPNNGKGAPQHQFSEGIMFEYRHFDQQNITPVYEFGYGLSYTTFSY
SNLRVRPMRANKYVPATGMTKPAPRLGHSSTKYADYLFPGGFKGVTKYVYPWLTSTDPKE
ASGDKNYGMPLEDYVPPNANNGDAQPVLPASGVPGGNPGLFEDLYKVSAVITNDGDRVGE
EVPQLYISLGGDRNAKVVLRGFDRIRLAPRQRFRWRTTITRRDISNWDPASQDWVMTEHP
KIVYVGSSSRNLPLQAPLPPPNLA
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Esculin
 Drug Info Investigative Appendicitis ICD11: DB10 [1]
References
1 A prodrug approach to the use of coumarins as potential therapeutics for superficial mycoses. PLoS One. 2013 Nov 18;8(11):e80760.

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