Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1049)
DME Name Dihydrofolate reductase (folA), Escherichia coli
Synonyms DHF reductase; 5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase; Bifunctional TS-DHFR; BmDHFR; Bacterial DFR-TS; Bacterial DHFR; TC_0902; folA
Gene Name folA
UniProt ID
DYR_ECOLI
Gene ID
944790
EC Number    EC: 1.5.1.3     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-NH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.5.1.3
Lineage    Species: Escherichia coli     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Escherichia
Species: Escherichia coli
Subspecies: Escherichia coli K-12
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
Structure
1DDR ; 1DDS ; 1DHI ; 1DHJ ; 1DRA ; 1DRB ; 1DRE ; 1DRH ; 1DYH ; 1DYI ; 1DYJ ; 1JOL ; 1JOM ; 1RA1 ; 1RA2 ; 1RA3 ; 1RA8 ; 1RA9 ; 1RB2 ; 1RB3 ; 1RC4 ; 1RD7 ; 1RE7 ; 1RF7 ; 1RG7 ; 1RH3 ; 1RX1 ; 1RX2 ; 1RX3 ; 1RX4 ; 1RX5 ; 1RX6 ; 1RX7 ; 1RX8 ; 1RX9 ; 1TDR ; 2ANO ; 2ANQ ; 2D0K ; 2DRC ; 2INQ ; 3DAU ; 3DRC ; 3K74 ; 3KFY ; 3OCH ; 3QL3 ; 3QYL ; 3QYO ; 3R33 ; 4DFR ; 4EIG ; 4EIZ ; 4EJ1 ; 4FHB ; 4GH8 ; 4I13 ; 4I1N ; 4KJJ ; 4KJK ; 4KJL ; 4NX6 ; 4NX7 ; 4PDJ ; 4X5F ; 4X5G ; 4X5H ; 4X5I ; 4X5J ; 5CC9 ; 5CCC ; 5DFR ; 5E8Q ; 5EAJ ; 5UIH ; 5UII ; 5UIO ; 5UIP ; 5UJX ; 5W3Q ; 5Z6F ; 5Z6J ; 5Z6K ; 5Z6L ; 5Z6M ; 6CQA ; 6DFR ; 6MR9 ; 6MT8 ; 6MTH ; 7DFR
Pathway Folate biosynthesis (ecj00790 )
Metabolic pathways (ecj01100 )
One carbon pool by folate (ecj00670 )
Function This enzyme is key enzyme in folate metabolism and can catalyze an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. And it also slowly reduces folate to 5,6,7,8-tetrahydrofolate.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Folic acid
 Drug Info Approved Vitamin deficiency ICD11: 5B55 [1], [2]
References
1 Measurement of the uptake of radioactive para-aminobenzoic acid monitors folate biosynthesis in Escherichia coli K-12. Anal Biochem. 1994 Feb 1;216(2):427-30.
2 The influence of CsgD on the expression of genes of folate metabolism and hmp in Escherichia coli K-12. Arch Microbiol. 2013 Aug;195(8):559-69.

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