| General Information of DME (ID: DME1059) |
| DME Name |
Fumarate reductase flavoprotein (frdA), Wolinella succinogenes
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| Synonyms |
Flavocytochrome c; Methylmenaquinol:fumarate reductase; Flavocytochrome c3; Fcc3; WS0831; Bacterial frdA
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| Gene Name |
frdA
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| UniProt ID |
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| EC Number |
EC: 1.3.5.4 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.3.5.4
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| Lineage |
Species: Wolinella succinogenes (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Wolinella
Species: Wolinella succinogenes
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Interactome(loading-time for this interactome depdends on the speed of web connection)
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Interactions between Host Protein and DME (HOSPPI)  Jump to Detailed Interactome Data |
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MKVQYCDSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVKRSHSAAAQGGMQASLGNSKM
SDGDNEDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIRELAAWGVPWTRIHKGDRMAIIN
AQKTTITEEDFRHGLIHSRDFGGTKKWRTCYTADATGHTMLFAVANECLKLGVSIQDRKE
AIALIHQDGKCYGAVVRDLVTGDIIAYVAKGTLIATGGYGRIYKNTTNAVVCEGTGTAIA
LETGIAQLGNMEAVQFHPTPLFPSGILLTEGCRGDGGILRDVDGHRFMPDYEPEKKELAS
RDVVSRRMIEHIRKGKGVQSPYGQHLWLDISILGRKHIETNLRDVQEICEYFAGIDPAEK
WAPVLPMQHYSMGGIRTDYRGEAKLKGLFSAGEAACWDMHGFNRLGGNSVSEAVVAGMIV
GEYFAEHCANTQVDLETKTLEKFVKGQEAYMKSLVESKGTEDVFKIKNRMKDVMDDNVGI
FRDGPHLEKAVKELEELYKKSKNVGIKNKRLHANPELEEAYRVPMMLKVALCVAKGALDR
TESRGAHNREDYPKRDDINWLNRTLASWPNPEQTLPTLEYEALDVNEMEIAPGYRGYGAK
GNYIENPLSVKRQEEIDKIQSELEAAGKDRHAIQEALMPYELPAKYKARNERLGDK
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| Structure |
1E7P
; 1QLB
; 2BS2
; 2BS3
; 2BS4
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| Pathway |
Biosynthesis of secondary metabolites (wsu01110 ) |
| Butanoate metabolism (wsu00650 ) |
| Carbon metabolism (wsu01200 ) |
| Citrate cycle (TCA cycle) (wsu00020 ) |
| Metabolic pathways (wsu01100 ) |
| Microbial metabolism in diverse environments (wsu01120 ) |
| Oxidative phosphorylation (wsu00190 ) |
| Pyruvate metabolism (wsu00620 ) |
| Two-component system (wsu02020 ) |
| Function |
This enzyme utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. The enzyme is known as complex II of the electron transfer chain, similarly to succinate dehydrogenase (quinone), to which it is closely related.
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