Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1102)
DME Name Arylamine N-acetyltransferase (NAT), Morganella morganii
Synonyms N-hydroxyarylamine O-acetyltransferase; nhoA; BED45_23050; LR61_11020
Gene Name NAT
UniProt ID
A0A0A2RAD0_MORMO
EC Number    EC: 2.3.1.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.5
Lineage    Species: Morganella morganii     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Morganellaceae
Genus: Morganella
Species: Morganella morganii
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKDISFYLTRLNIKENIKIDNYFLFRFHHAHFYSVPFENFSMKENASSCSLSQIIANKII
FNKRGGICFEFAKLLESFFSYTGFVYRTRLARVLIPLMTPATHQLFIISVKGEEWIFDVG
FGARGPRAPLRMVDGYVHEHAFLSSKVSRHPAYGWVVSVKENSRLNADWEDIYAFHDTET
FLPDISMAYFYTLHSPESLLNTHKVASLPTENGRISIRNNVFTEVNGLSSCSADITDNEE
LSQLLSGKFGISIHPQQLQ
Function This enzyme is wide specificity for aromatic amines, including serotonin and it also catalyses acetyl-transfer between arylamines without CoA.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Asacolitin
 Drug Info Investigative Inflammatory bowel disease ICD11: DD72 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR007496 Asacolitin N-acetyl-5-ASA Conjugation - N-acetylation Asacolitin [1]
MR007114 Dihydralazine Unclear Unclear - Unclear Dihydralazine [2]
References
1 Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.
2 The influence of the acetylator phenotype for the clinical use of dihydralazine. Int J Clin Pharmacol Ther Toxicol. 1985 Apr;23 Suppl 1:S74-8.

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