Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1136)
DME Name Fructokinase (scrK), Fusobacterium mortiferum
Synonyms D-fructose(D-mannose)kinase; D-fructose kinase; Fructo kinase; D-fructokinase; cscK, OsFK; scrK; CL6EHI_054510
Gene Name scrK
UniProt ID
SCRK_FUSMR
EC Number    EC: 2.7.1.4     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.1.4
Lineage    Species: Fusobacterium mortiferum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium mortiferum
Subspecies: Fusobacterium mortiferum ATCC 25557
Subspecies: Fusobacterium mortiferum ATCC 9817
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MIIGAVEAGGTKFVDGVGNEKGEIFER
Function This enzyme has fructokinase activity, involved metal ion binding, and cellular carbohydrate catabolic process.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          2 Drugs
M-7403
 Drug Info Phase 1/2 Prostate cancer ICD11: 2C82 [1], [2]
LS-69767
 Drug Info Phase 1 Chronic myelogenous leukaemia ICD11: 2A20 [3]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Sucrose
 Drug Info Investigative Prematurity retinopathy ICD11: 9B71 [1]
Full List of Metabolic Reactions (MR) Catalyzed by This DME
MR ID Reactant Product MR Type Source Drug REF
MR005786 LS-69767 Fructose-1-phosphate Conjugation - Phosphorylation LS-69767 [3]
References
1 Sugar metabolism by fusobacteria: regulation of transport, phosphorylation, and polymer formation by Fusobacterium mortiferum ATCC 25557. Infect Immun. 1991 Dec;59(12):4547-54.
2 Clinical Fusobacterium mortiferum isolates cluster with undifferentiated Clostridium rectum species based on 16S rRNA gene phylogenetic analysis. Ann Clin Lab Sci. 2016 May;46(3):279-81.
3 Toxin and Toxin Target Database (T3DB):LS-69767

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