Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1138)
DME Name Alpha-glucosidase (aglA), Blautia obeum
Synonyms Oligo-1,6-glucosidase; 6-phospho-alpha-glucosidase 1; DW040_17105; ERS852394_00764; malL_1
Gene Name malL_1
UniProt ID
A0A173ZA10_9FIRM
Gene ID
42449350
EC Number    EC: 3.2.1.20     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.20
Lineage    Species: Blautia obeum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Lachnospiraceae
Genus: Blautia
Species: Blautia obeum
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MEKKWWKESVVYQIYPKSFKDSNGDGVGDIRGIIQKLDYLKELGVNVLWISPMLESPQDD
NGYDISDYRRIYKEYGTMEDYEELLSEAHKRDIRILMDLVVNHTSDEHNWFIESRKSKDN
PYRDYYIWKDPVNGKEPNNWGGVFGGSAWEYDAQTQMYYLHLFSKKQPDLNWENEKVRQE
VYDMMTFWCEKGIDGFRMDVISMISKDQAFPDGKMNNSLYGDFGPYCVHGPRIHEFLQEM
NREVLSRYDIMTVGETSGVTIEEAQKYAGEAGKELNMVFQFEHVDNGSGDYGKWTTEKYD
FKEFKRIMIKWQEELQGKAWNSLFLGNHDQPRSVSRFGNDNPAYRETSAKMLATCLHMMQ
GTPYVYQGEELGMTNVYFDKLEDYRDIESINFFTELTESGLMTPEYMMKCLMLRSRDNAR
TPMQWDDSEQAGFTDGESWIKVNPNYKEINAAQQLKDPNSIFHYYQKLISLRKEKDIIVY
GEFEPLYRDDEQIFAYTRKLDQEKLLTVCNFSDKNAEMEIPEEFKGAECLITNLDRTVFE
GKIVLKPYEAFVLYKK
Function This enzyme is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). And it hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, i.e. trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphate. Moreover, it can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphate. However, it fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphate.
Full List of Drug(s) Metabolized by This DME
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
M-7403
 Drug Info Phase 1/2 Prostate cancer ICD11: 2C82 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Isomaltose
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch. FASEB J. 2010 Oct;24(10):3939-49.

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