Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1150)
DME Name CDP-alcohol phosphatidyltransferase (pgsA), Streptococcus oralis
Synonyms CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; pgsA; D8864_08980; SK143_1874; SORDD14_01192; SORDD17_00429; SORDD25_01474; SORDD30_01510
Gene Name pgsA
UniProt ID
A0A081R409_STROR
EC Number    EC: 2.7.8.5     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.8.5
Lineage    Species: Streptococcus oralis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Streptococcaceae
Genus: Streptococcus
Species: Streptococcus oralis
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human oral cavity.
Sequence
MKKEQIPNVLTIGRILFIPLFILILTLGHSQGSHLLAAIIFAVASVTDYLDGYLARKWNV
VSNFGKFADPMADKLLVMSAFIMLIELGMAPAWVVAIIICRELAVTGLRLLLVETGGTVL
AAAMPGKIKTFSQMFAIIFLLLHWNLIGQLLLYIALFFTIYSGYDYFKGSAHVFKGTFGS
K
Function This enzyme catalyzes the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Daptomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
References
1 Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Antimicrob Agents Chemother. 2019 Jan 29;63(2). pii: e01531-18.

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