| General Information of DME (ID: DME1161) |
| DME Name |
N-acetylneuraminate lyase (nanA), Fusobacterium nucleatum
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| Synonyms |
Sialic acid aldolase; N-acetylneuraminate pyruvate-lyase; Sialic acid lyase; N-acetylneuraminic acid aldolase; Sialate lyase; Neu5Ac lyase; NAL; FN1475; nanA
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| Gene Name |
nanA
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| UniProt ID |
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| Gene ID |
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| EC Number |
EC: 4.1.3.3 (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Oxo-acid-lyase
EC: 4.1.3.3
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| Lineage |
Species: Fusobacterium nucleatum (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium nucleatum
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Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
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| Tissue Distribution |
Primarily distributed in human gut.
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| Sequence |
MKGIYSALMVPYNEDGSINEKGLREIIRYNIDKMKVDGLYVGGSTGENFMISTEEKKRVF
EIAIDEAKDSVNLIAQVGSINLNEAVELGKYVTKLGYKCLSAVTPFYYKFDFSEIKDYYE
TIVRETGNYMIIYSIPFLTGVNMSLSQFGELFENEKIIGVKFTAGDFYLLERVRKAFPDK
LIFAGFDEMLLPATVLGVDGAIGSTYNINGIRAKQIFELAKNSKIDEALKIQHTTNDLIE
GILSNGLYQTIKEILKLEGVDAGYCRKPMKKISQKQIEFAKELHKKFLKN
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| Structure |
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| Pathway |
Amino sugar and nucleotide sugar metabolism (fnu00520 ) |
| Metabolic pathways (fnu01100 ) |
| Function |
This enzyme catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. It also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
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