Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1171)
DME Name D-psicose 3-epimerase (DPEase), Ruminiclostridium cellulolyticum
Synonyms Psicose 3-epimerase; D-psicose-epimerase; Psicose epimerase; DPEase; Ccel_0941; dpe
Gene Name DPEase
UniProt ID
DPES_RUMCH
EC Number    EC: 5.1.3.30     (Click to Show/Hide the Complete EC Tree)
Isomerase
Racemase/epimerase
Carbohydrate racemase/epimerase
EC: 5.1.3.30
Lineage    Species: Ruminiclostridium cellulolyticum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Hungateiclostridiaceae
Genus: Ruminiclostridium
Species: Ruminiclostridium cellulolyticum
Subspecies: Ruminiclostridium cellulolyticum H10
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MKHGIYYAYWEQEWEADYKYYIEKVAKLGFDILEIAASPLPFYSDIQINELKACAHGNGI
TLTVGHGPSAEQNLSSPDPDIRKNAKAFYTDLLKRLYKLDVHLIGGALYSYWPIDYTKTI
DKKGDWERSVESVREVAKVAEACGVDFCLEVLNRFENYLINTAQEGVDFVKQVDHNNVKV
MLDTFHMNIEEDSIGGAIRTAGSYLGHLHTGECNRKVPGRGRIPWVEIGEALADIGYNGS
VVMEPFVRMGGTVGSNIKVWRDISNGADEKMLDREAQAALDFSRYVLECHKHS
Structure
3VNI ; 3VNJ ; 3VNK ; 3VNL ; 3VNM
Function This enzyme catalyzes the reversible epimerization of D-fructose at the C3 position to yield D-psicose and it is highly specific for D-psicose and shows very low activity with D-tagatose.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
D-fructose
 Drug Info Investigative Functional nausea/vomiting ICD11: DD90 [1], [2]
References
1 Highly efficient production of Clostridium cellulolyticum H10 D-psicose 3-epimerase in Bacillus subtilis and use of these cells to produce D-psicose. Microb Cell Fact. 2018 Nov 28;17(1):188.
2 Anaerobic bacteria as producers of antibiotics. Appl Microbiol Biotechnol. 2012 Oct;96(1):61-7.

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