Details of the Drug Metabolized by Drug-Metabolizing Enzyme (DME)

General Information of Drug (ID: DR2156)
Drug Name
D-fructose
Synonyms
D-Arabino-Hex-2-ulo-Pyranose; D-Fructopyranose; D-Fructopyranoside; D-Fructose; D-arabino-Hex-2-ulopyranose; Fructopyranose; Fructopyranoside; Fructose; LKDRXBCSQODPBY-VRPWFDPXSA-N; Q27117234; SCHEMBL239448; AKOS004910390; C05003; CHEBI:37714; CHEMBL2325229; CTK2F9011; D-Fru; EB37038E-44A6-4AF7-B0D8-47A315AD2F74; F0317; Fru; [14C]-Fructose
Indication Functional nausea/vomiting [ICD11: DD90] Investigative [1]
Structure
3D MOL 2D MOL
Pharmaceutical Properties Molecular Weight 180.16 Topological Polar Surface Area 110
Heavy Atom Count 12 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 6
Cross-matching ID
PubChem CID
2723872
ChEBI ID
CHEBI:37714
CAS Number
7660-25-5
Formula
C6H12O6
Canonical SMILES
C1C(C(C(C(O1)(CO)O)O)O)O
InChI
1S/C6H12O6/c7-2-6(11)5(10)4(9)3(8)1-12-6/h3-5,7-11H,1-2H2/t3-,4-,5+,6?/m1/s1
InChIKey
LKDRXBCSQODPBY-VRPWFDPXSA-N
The Metabolic Roadmap of This Drug
The Full List of Drug Metabolites (DM) of This Drug
DM Name DM ID PubChem ID Reaction DM Level REF
Fructose-6-phosphate DM005858
69507
Unclear 1 [2]
Allulose-6-P DM005859
40467872
Unclear 2 [2]
D-Allulose DM005860
441036
Unclear 3 [2]
The Full List of Metabolic Reaction (MR) of This Drug
MR ID Reactant Product MR Type DME REF
MR006267 D-fructose Fructose-6-phosphate Unclear mak [2]
MR006268 Fructose-6-phosphate Allulose-6-P Unclear alsE [2]
MR006269 Allulose-6-P D-Allulose Unclear A6PP [2]
Drug-Metabolizing Enzyme(s) (DME) Metabolizing This Drug
DME Name DME Info Species Uniprot ID EC Number REF
allulose-6-phosphate phosphatase (A6PP) DMEN291 Escherichia coli Not Available Not Available [2]
D-allulose-6-phosphate 3-epimerase (alsE) DMEN313 Escherichia coli
ALSE_ECOLI
5.1.3.-
[2]
D-psicose 3-epimerase (DPEase) DME1171 Ruminiclostridium cellulolyticum
DPES_RUMCH
5.1.3.30
[3] , [4]
Fructokinase (mak) DMEN312 Escherichia coli
MAK_ECOLI
2.7.1.4
[2]
References
1 Plasma D-glucose, D-fructose and insulin responses after oral administration of D-glucose, D-fructose and sucrose to normal rats. J Am Coll Nutr. 2004 Oct;23(5):414-9.
2 Metabolically Engineered Escherichia coli for Conversion of D-Fructose to D-Allulose via Phosphorylation-Dephosphorylation
3 Highly efficient production of Clostridium cellulolyticum H10 D-psicose 3-epimerase in Bacillus subtilis and use of these cells to produce D-psicose. Microb Cell Fact. 2018 Nov 28;17(1):188.
4 Anaerobic bacteria as producers of antibiotics. Appl Microbiol Biotechnol. 2012 Oct;96(1):61-7.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.