Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1184)
DME Name VanB ligase (vanB), Enterococcus faecium
Synonyms Vancomycin B-type resistance protein VanB; D-alanylalanine synthetase VanB; D-alanine--D-alanine ligase VanB; D-Ala-D-Ala ligase VanB; vanB
Gene Name vanB
UniProt ID
Q58F99_ENTFC
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus faecium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecium
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MNRIKVAIIFGGCSEEHDVSVKSAIEIAANIDTEKFDPHYIGITKNGVWKLCKKPCTEWE
ADSLPAILSPDRKTHGLLVMKESEYETRRIDVAFPVLHGKCGEDGAIQGLFVLSGIPYVG
CDIQSSAACMDKSLAYILTKNAGIAVPEFQMIDKGDKPEAGALTYPVFVKPARSGSSFGV
TKVNGTEELNAAIEAAGQYDGKILIEQAISGCEVGCAVMGNEDDLIVGEVDQIRLSHGIF
RIHQENEPEKGSENAMITVPADIPVEERNRVQETAKKVYRVLGCRGLARVDLFLQEDGGI
VLNEVNTLPGFTSYSRYPRMMAAAGITLPALIDSLITLALKR
Function This enzyme is involved with UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---L-lysine ligase (EC 6.3.2.7) or UDP-N-acetylmuramoyl-L-alanyl-D-glutamate---2,6-diaminopimelate ligase (EC 6.3.2.13), UDP-N-acetylmuramate---L-alanine ligase (EC 6.3.2.8), UDP-N-acetylmuramoyl-L-alanine---D-glutamate ligase (EC 6.3.2.9) and UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase (EC 6.3.2.10) in the synthesis of a cell-wall peptide.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Vancomycin
 Drug Info Approved Methicillin-resistant staphylococcus infection ICD11: 1D01 [1]
References
1 Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother. 1993 Aug;37(8):1563-71.

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