Details of Xenobiotics-DME Interaction (XEOTIC)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1184)
DME Name VanB ligase (vanB), Enterococcus faecium DME Info
UniProt ID
Q58F99_ENTFC
EC Number    EC: 6.3.2.4     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-nitrogen ligase
Peptide synthase
EC: 6.3.2.4
Lineage    Species: Enterococcus faecium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Enterococcaceae
Genus: Enterococcus
Species: Enterococcus faecium
Interactome
Interactions between Xenobiotics and DME (XEOTIC)
      Amino Acid(s), Peptide(s) or Protein(s)
                  Peptide Click to Show/Hide the Full List of Xenobiotics:      25 Xenobiotics
                              Bacteriocin 32 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02373   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin 32 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [1]
                              Bacteriocin hiracin-JM79 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02377   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin hiracin-JM79 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [2]
                              Bacteriocin lacticin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03771   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lacticin Q inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [3]
                              Bacteriocin lactocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03775   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Bacteriocin lactocyclicin Q inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 0.71 microM) [4], [5]
                              Beta-defensin BD-38 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02440   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Beta-defensin BD-38 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [6]
                              Brevinin-1HN1 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02524   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1HN1 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 19 microM) [7]
                              Brevinin-1V Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02567   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Brevinin-1V inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 19 microM) [7], [8]
                              Carnobacteriocin CbnB2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02718   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Carnobacteriocin CbnB2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [9]
                              Cathelicidin-BF Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO02743   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Cathelicidin-BF inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 150 ug/ml) [10], [11]
                              D-amino-acid pexiganan MSI-214 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03073   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation D-amino-acid pexiganan MSI-214 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 4 ug/ml) [12]
                              Enterocin L50A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03255   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin L50A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [13], [14]
                              Enterocin L50B Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03256   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin L50B inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [13], [14]
                              Enterocin P Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03257   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin P inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 0.002 ug/ml) [15], [16]
                              Enterocin X alpha Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03259   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Enterocin X alpha inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 0.0508 microM) [17]
                              Garvicin ML Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03473   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Garvicin ML inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [18]
                              Hagfish HFIAP-1/2 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03556   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-1/2 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 4-8 ug/ml) [19]
                              Hagfish HFIAP-3 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03557   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hagfish HFIAP-3 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 4-8 ug/ml) [19]
                              Hematopoietic antimicrobial MgCath37 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03540   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Hematopoietic antimicrobial MgCath37 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 4-8 ug/ml) [19]
                              Leucocyclicin Q Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO03857   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Leucocyclicin Q inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium (MIC = 0.038 microM) [5]
                              Mundticin KS Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04151   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Mundticin KS inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [20]
                              Penocin A Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04521   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Penocin A inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [21], [22]
                              Pleurocidin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04640   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Pleurocidin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [23]
                              S. litura moricin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO04877   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation S. litura moricin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [24]
                              Tricyclic peptide MS-271 Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05169   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Tricyclic peptide MS-271 inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [25]
                              Variacin Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO05228   XEOTIC Info Gene Form Protein
                                 Classification Peptide
                                 DME Modulation Variacin inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [26]
      Other Chemical Compound(s) or Element(s)
                  Chemical Compound Click to Show/Hide the Full List of Xenobiotics:        2 Xenobiotics
                              3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01961   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 3-(3-fluorophenyl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [27]
                              3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one Click to Show/Hide the Detail Inhibition
                                 XEOTIC ID XEO01966   XEOTIC Info Gene Form Protein
                                 Classification Chemical Compound
                                 DME Modulation 3-(pyridin-3-yl)-5-(3-ethoxy-4-hydroxybenzylidene)-2-thioxothiazolidin-4-one inhibits the drug-metabolizing activity of VanB ligase (vanB) from Enterococcus faecium [27]
References
1 Bac 32, a novel bacteriocin widely disseminated among clinical isolates of Enterococcus faecium. Antimicrob Agents Chemother. 2006 Apr;50(4):1202-12.
2 Amino acid and nucleotide sequence, adjacent genes, and heterologous expression of hiracin JM79, a sec-dependent bacteriocin produced by Enterococcus hirae DCH5, isolated from Mallard ducks (Anas platyrhynchos). FEMS Microbiol Lett. 2007 May;270(2):227-36.
3 Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria. Appl Environ Microbiol. 2007 May;73(9):2871-7.
4 Identification and characterization of lactocyclicin Q, a novel cyclic bacteriocin produced by Lactococcus spstrain QU 12. Appl Environ Microbiol. 2009 Mar;75(6):1552-8.
5 Identification and characterization of leucocyclicin Q, a novel cyclic bacteriocin produced by Leuconostoc mesenteroides TK41401. Appl Environ Microbiol. 2011 Nov;77(22):8164-70.
6 Identification on mouse chromosome 8 of new beta-defensin genes with regionally specific expression in the male reproductive organ. J Biol Chem. 2004 Mar 26;279(13):12421-6.
7 Novel antimicrobial peptides isolated from the skin secretions of Hainan odorous frog, Odorrana hainanensis. Peptides. 2012 Jun;35(2):285-90.
8 Amphibian skin peptides and their corresponding cDNAs from single lyophilized secretion samples: identification of novel brevinins from three species of Chinese frogs. Peptides. 2006 Jan;27(1):42-8.
9 Solution structure of carnobacteriocin B2 and implications for structure-activity relationships among type IIa bacteriocins from lactic acid bacteria. Biochemistry. 1999 Nov 23;38(47):15438-47.
10 Snake cathelicidin from Bungarus fasciatus is a potent peptide antibiotics. PLoS One. 2008 Sep 16;3(9):e3217.
11 Identification and characterization of novel reptile cathelicidins from elapid snakes. Peptides. 2008 Oct;29(10):1685-91.
12 In vitro antibacterial properties of pexiganan, an analog of magainin. Antimicrob Agents Chemother. 1999 Apr;43(4):782-8.
13 Enterocins L50A and L50B, two novel bacteriocins from Enterococcus faecium L50, are related to staphylococcal hemolysins. J Bacteriol. 1998 Apr;180(8):1988-94.
14 Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island. BMC Genomics. 2010 Apr 14;11:239.
15 Biochemical and genetic characterization of enterocin P, a novel sec-dependent bacteriocin from Enterococcus faecium P13 with a broad antimicrobial spectrum. Appl Environ Microbiol. 1997 Nov;63(11):4321-30.
16 Single nucleotide polymorphism analysis of the enterocin P structural gene of Enterococcus faecium strains isolated from nonfermented animal foods. Mol Nutr Food Res. 2006 Dec;50(12):1229-38.
17 Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides. Appl Environ Microbiol. 2010 Jul;76(13):4542-5.
18 Characterization of garvicin ML, a novel circular bacteriocin produced by Lactococcus garvieae DCC43, isolated from mallard ducks (Anas platyrhynchos). Appl Environ Microbiol. 2011 Jan;77(1):369-73.
19 Hagfish intestinal antimicrobial peptides are ancient cathelicidins. Peptides. 2003 Nov;24(11):1655-67.
20 Biochemical and genetic characterization of mundticin KS, an antilisterial peptide produced by Enterococcus mundtii NFRI 7393. Appl Environ Microbiol. 2002 Aug;68(8):3830-40.
21 Comparative genomics of the lactic acid bacteria. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15611-6.
22 Data mining and characterization of a novel pediocin-like bacteriocin system from the genome of Pediococcus pentosaceus ATCC 25745. Microbiology. 2006 Jun;152(Pt 6):1649-59.
23 Antimicrobial peptide pleurocidin synergizes with antibiotics through hydroxyl radical formation and membrane damage, and exerts antibiofilm activity. Biochim Biophys Acta. 2012 Dec;1820(12):1831-8.
24 Isolation, gene expression and solution structure of a novel moricin analogue, antibacterial peptide from a lepidopteran insect, Spodoptera litura. Biochim Biophys Acta. 2005 Aug 31;1752(1):83-92.
25 MS-271, a novel inhibitor of calmodulin-activated myosin light chain kinase from Streptomyces sp.--IIsolation, structural determination and biological properties of MS-271. Bioorg Med Chem. 1996 Jan;4(1):115-20.
26 Variacin, a new lanthionine-containing bacteriocin produced by Micrococcus varians: comparison to lacticin 481 of Lactococcus lactis. Appl Environ Microbiol. 1996 May;62(5):1799-802.
27 Aryl rhodanines specifically inhibit staphylococcal and enterococcal biofilm formation. Antimicrob Agents Chemother. 2009 Oct;53(10):4357-67.

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