Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1192)
DME Name AmpC beta-lactamase (ampC), Burkholderia multivorans
Synonyms Beta-lactamase ampC; Bacterial burkholderia beta-lactamase ampC; ampC; BMULJ_05519
Gene Name ampC
UniProt ID
A0A0H3KQ39_BURM1
EC Number    EC: 3.5.2.6     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Cyclic amide hydrolase
EC: 3.5.2.6
Lineage    Species: Burkholderia multivorans     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Burkholderiaceae
Genus: Burkholderia
Species: Burkholderia multivorans
Subspecies: Burkholderia multivorans ATCC 17616
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human lung.
Sequence
MRITVTRVVATLLVATAAIATTGRAAELTQAHIRQIVTQQVAPAMKQYAIPGVAIGVIVD
GKRYVFDYGVMSKDTGKPVTADTLFEIGSVSKTLTATLAADAQEGGELSLSDPVARYVPA
LNGKPAGALTLLELGTHTAGGLPQQVPDAIHDDATLIGYFDAWRPASVPGTQRVYSNVGI
GTLGWITAKAMKRDFAELMERRLFPALGMTHTYIDVPDARRADYAQGYTTDGTPIRMKPG
GLWQPAYGVRTTATDLLRFVQANMGGIDIAPRLQRAIERTHTGYFRAGPLTQDLIWEQYP
YPVALPTLLEGNASKMLSDAVPAVALTPPLAPQRNVWINKTGSTNGFSTYVAFVPAKRIG
FVMLANRRVPNEVRVEIAYRILASLGGAR
Pathway Two-component system (bmj02020 )
beta-Lactam resistance (bmj01501 )
Function This enzyme hydrolyzes beta-lactam.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Ampicillin
 Drug Info Approved Endocarditis ICD11: 1B12 [1]
Cephalothin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1]
      Drugs in Phase 4 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Imipenem
 Drug Info Phase 4 Acute pancreatitis ICD11: DC31 [1]
References
1 Characterization of the AmpC beta-Lactamase from Burkholderia multivorans. Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01140-18.

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