Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1206)
DME Name Beta-glucosidase (bglA), Fusobacterium mortiferum
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; Beta-glucosidase-related glycosidases; BN791_01499
Gene Name BN791_01499
UniProt ID
R7LVY8_9FUSO
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Fusobacterium mortiferum     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Fusobacteria
Class: Fusobacteriia
Order: Fusobacteriales
Family: Fusobacteriaceae
Genus: Fusobacterium
Species: Fusobacterium mortiferum
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSVTLKEKLYQMFILGTDGGYYKELLKEGLGGIIFFSKDIQTKTQFKSLIDDIKLISKIP
PFLSIDQEGGRVERTENIHNGKKYLSAKFAFEKGEKFLKSQTEEISKELKSYGINLNFAP
CIDTNTNPNNPIIGVRAFSSNPDEVIKAEKIVSKTYEENGIIPCVKHFPGHGDANADSHL
TLPKIDLSLKDMEETHIKPFKSAIENGIDMVMVAHLFCTCFEKEEVPTSLSKNAIDYLRN
NLNFDKVAISDDMVMKGVAKFGDVEACEMGIKAGLNLFIYRFSDEKTSNIIQEIYKKAQK
DNLLKEKIENSYNKIMALKSKYNIA
Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          3 Drugs
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [1]
Gypenoside XVII
 Drug Info Investigative Arteriosclerosis obliterans ICD11: BD40 [1]
Glucopyranosyl oleanolate
 Drug Info Investigative Discovery agent ICD: N.A. [1]
References
1 Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. Biol Pharm Bull. 2000 Dec;23(12):1481-5.

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