Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1207)
DME Name Beta-glucosidase (bglA), Lactobacillus rhamnosus
Synonyms Periplasmic beta-glucosidase; Glucan endo-1 3-beta-D-glucosidase; Beta-D-glucosidase; BGK71_01895
Gene Name bglA
UniProt ID
A0A249DCH3_LACRH
EC Number    EC: 3.2.1.21     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Glycosylase
O/S-glycosyl compound glycosidase
EC: 3.2.1.21
Lineage    Species: Lactobacillus rhamnosus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: Lactobacillus rhamnosus
Subspecies: Lactobacillus rhamnosus HN001
Subspecies: Lactobacillus rhamnosus subsp. Rhamnosus NCTC 10302
Interactome
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       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTQQQLYTPKGFPKNFLWGGAIAANQAEGAWQTDGRGPSQADIMLLPEKYSRLGSFGEHV
TRADIERALADKSGNYPRRRGIDFFHTYDSDLDLMKEMGFNTFRTSFSWSRIFPNGDEKE
PNEKGLKFYDKLIQKMLDLDITPVMTISHYEMPLNLITKYGGWENPEMINFFNRFAQVLL
DRYHDKVKYWIVFNQVNDVYGWGEFAGLGILKENQPNEKQAKFQAVHHQFIANAQTVKYG
HQIDNDIKIGMMLGLTNVYPASTKPQDVMATYKRWNKDTFFFSDVLARGEYPGYMLRYFE
DNNIQLSIDQKELDLIKNNPVDFIAFSYYSSSLISADTPDSLLPNPELEESIWGWSFDPI
GFRYGFNVLWDRYHLPLFVAENGLGALDTVEDNKIHDAYRIKYLKAHIKQMKEAIKDGVH
IFGYAAWGPIDIVSYSQAEMSKRYGFVYVDLDDKGNGTGKRIRKDSFYWYQKVIESNGDQ
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Function This enzyme has wide specificity for beta-D-glucosides such as beta-D-galactosides, alpha-L-arabinosides, beta-D-xylosides, beta-D-fucosides.
Full List of Drug(s) Metabolized by This DME
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          4 Drugs
CCG-208408
 Drug Info Preclinical Depression ICD11: 6A71 [1]
HY-N0040
 Drug Info Preclinical Rotavirus gastroenteritis ICD11: 1A22 [2]
Ginsenoside Rc
 Drug Info Investigative Diabetes mellitus ICD11: 5A10 [2]
Ginsenoside Rb1
 Drug Info Investigative Obesity ICD11: 5B81 [2]
References
1 Catabolism of citrus flavanones by the probiotics Bifidobacterium longum and Lactobacillus rhamnosus. Eur J Nutr. 2018 Feb;57(1):231-242.
2 Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Appl Microbiol Biotechnol. 2017 Jul;101(13):5427-5437.

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