Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1233)
DME Name Cytochrome P450 105D7 (cyp105), Streptomyces avermitilis
Synonyms Cytochrome P450 family 105 subfamily D member 7; Pentalenic acid synthase; SAV_7469; cyp105d7; cyp28
Gene Name cyp28
UniProt ID
CYP28_STRAW
EC Number    EC: 1.14.15.11     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.11
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MTEPGTSVSAPVAFPQDRTCPYDPPTAYDPLREGRPLSRVSLYDGRSVWVVTGHAAARAL
LSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQRRMLVPSFTLKRAAALR
PRIQETVDGLLDAMEAQGPPAELVSAFALPLPSMVICALLGVPYADHDFFESQSRRLLRG
PGIAEVQDARAQLDDYLYALIDRKRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLI
AGHETTANMISLGTFTLLRHPEQLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIE
VAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAE
MEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLELPVTW
Structure
4UBS
Pathway Biosynthesis of secondary metabolites (sma01110 )
Biosynthesis of various secondary metabolites (sma00999 )
Function This enzyme is a P-450 heme-thiolate protein, and it catalyzes the conversion of 1-deoxypentalenic acid to pentalenic acid in the biosynthesis of neopentalenolactone antibiotic.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Diclofenac sodium
 Drug Info Approved Osteoarthritis ICD11: FA00 [1]
      Drugs in Phase 1 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
BE-14348A
 Drug Info Phase 1 Viral hepatitis ICD11: 1E51 [2], [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          2 Drugs
ML-236B
 Drug Info Preclinical Hypertriglyceridaemia ICD11: 5C80 [2], [1]
Q-27137207
 Drug Info Investigative Discovery agent ICD: N.A. [2], [1]
      Experimental Enzyme Kinetic Data of Drugs Click to Show/Hide the Full List of Drugs:          2 Drugs
Diclofenac sodium
 Drug Info Approved Osteoarthritis Kcat/Km = 0.15 s-1microM-1 [2], [1]
ML-236B
 Drug Info Preclinical Hypertriglyceridaemia Km = 39.1 microM [2], [1]
References
1 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
2 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.

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