Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME1233)
DME Name Cytochrome P450 105D7 (cyp105), Streptomyces avermitilis DME Info
UniProt ID
CYP28_STRAW
EC Number    EC: 1.14.15.11     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.11
Lineage    Species: Streptomyces avermitilis     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Streptomycetales
Family: Streptomycetaceae
Genus: Streptomyces
Species: Streptomyces avermitilis
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      Drug co-metabolism
               Cometabolized drug: Diclofenac sodium Click to Show/Hide the Full List of HOSPPI:      12 HOSPPI
                            Cholesterol 24-hydroxylase (CYP46A1) Click to Show/Hide the Cometabolization Info
DME ID DME0028 DME Info
Uniprot ID
CP46A_HUMAN
Interaction Name CYP46A1-cyp105 interaction [1], [2], [3]
Description The interaction, between human Cholesterol 24-hydroxylase and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A1 (CYP1A1) Click to Show/Hide the Cometabolization Info
DME ID DME0006 DME Info
Uniprot ID
CP1A1_HUMAN
Interaction Name CYP1A1-cyp105 interaction [1], [2], [4]
Description The interaction, between human Cytochrome P450 1A1 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 1A2 (CYP1A2) Click to Show/Hide the Cometabolization Info
DME ID DME0003 DME Info
Uniprot ID
CP1A2_HUMAN
Interaction Name CYP1A2-cyp105 interaction [1], [2], [5]
Description The interaction, between human Cytochrome P450 1A2 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2B6 (CYP2B6) Click to Show/Hide the Cometabolization Info
DME ID DME0020 DME Info
Uniprot ID
CP2B6_HUMAN
Interaction Name CYP2B6-cyp105 interaction [1], [2], [6]
Description The interaction, between human Cytochrome P450 2B6 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C18 (CYP2C18) Click to Show/Hide the Cometabolization Info
DME ID DME0017 DME Info
Uniprot ID
CP2CI_HUMAN
Interaction Name CYP2C18-cyp105 interaction [1], [2], [4]
Description The interaction, between human Cytochrome P450 2C18 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C8 (CYP2C8) Click to Show/Hide the Cometabolization Info
DME ID DME0018 DME Info
Uniprot ID
CP2C8_HUMAN
Interaction Name CYP2C8-cyp105 interaction [1], [2], [7]
Description The interaction, between human Cytochrome P450 2C8 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 2C9 (CYP2C9) Click to Show/Hide the Cometabolization Info
DME ID DME0019 DME Info
Uniprot ID
CP2C9_HUMAN
Interaction Name CYP2C9-cyp105 interaction [1], [2], [8]
Description The interaction, between human Cytochrome P450 2C9 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Cytochrome P450 3A4 (CYP3A4) Click to Show/Hide the Cometabolization Info
DME ID DME0001 DME Info
Uniprot ID
CP3A4_HUMAN
Interaction Name CYP3A4-cyp105 interaction [1], [2], [9]
Description The interaction, between human Cytochrome P450 3A4 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            Mephenytoin 4-hydroxylase (CYP2C19) Click to Show/Hide the Cometabolization Info
DME ID DME0021 DME Info
Uniprot ID
CP2CJ_HUMAN
Interaction Name CYP2C19-cyp105 interaction [1], [2], [4]
Description The interaction, between human Mephenytoin 4-hydroxylase and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A3 (UGT1A3) Click to Show/Hide the Cometabolization Info
DME ID DME0041 DME Info
Uniprot ID
UD13_HUMAN
Interaction Name UGT1A3-cyp105 interaction [1], [2], [10]
Description The interaction, between human UDP-glucuronosyltransferase 1A3 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 1A9 (UGT1A9) Click to Show/Hide the Cometabolization Info
DME ID DME0042 DME Info
Uniprot ID
UD19_HUMAN
Interaction Name UGT1A9-cyp105 interaction [1], [2], [10]
Description The interaction, between human UDP-glucuronosyltransferase 1A9 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
                            UDP-glucuronosyltransferase 2B7 (UGT2B7) Click to Show/Hide the Cometabolization Info
DME ID DME0040 DME Info
Uniprot ID
UD2B7_HUMAN
Interaction Name UGT2B7-cyp105 interaction [1], [2], [11]
Description The interaction, between human UDP-glucuronosyltransferase 2B7 and Cytochrome P450 105D7 from Streptomyces avermitilis which collectively metabolize the drug Diclofenac sodium, is reported to affect the efficacy, safety or bioavailability of this drug via interfering with it metabolism.
References
1 The metagenome of Caracolus marginella gut microbiome using culture independent approaches and shotgun sequencing. Data Brief. 2017 Nov 22;16:501-505.
2 Hydroxylation of Compactin (ML-236B) by CYP105D7 (SAV_7469) from Streptomyces avermitilis. J Microbiol Biotechnol. 2017 May 28;27(5):956-964.
3 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
4 Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70.
5 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
6 Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 1;58(5):787-96.
7 Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry. 2004 Dec 14;43(49):15379-92.
8 New insights into the structural features and functional relevance of human cytochrome P450 2C9. Part I. Curr Drug Metab. 2009 Dec;10(10):1075-126.
9 Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. Drug Metab Dispos. 2000 Sep;28(9):1043-50.
10 Glucuronidation of nonsteroidal anti-inflammatory drugs: identifying the enzymes responsible in human liver microsomes. Drug Metab Dispos. 2005 Jul;33(7):1027-35.
11 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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