Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1238)
DME Name Ribosomal 23S RNA methyltransferase Erm (erm), Corynebacterium jeikeium
Synonyms Ribosomal RNA methyltransferase Erm; 23S rRNA methyltransferase Erm; 23S ribosomal RNA methyltransferase Erm; NCTC11913_00479; erm(X)
Gene Name erm(X)
UniProt ID
A0A381KDL2_CORJE
EC Number    EC: 2.1.1.182     (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Methyltransferase
EC: 2.1.1.182
Lineage    Species: Corynebacterium jeikeium     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium jeikeium
Interactome
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       Interactions between Host Protein and DME (HOSPPI)                     
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      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human skin.
Sequence
MSTYGYGRHEHGQNFLTDHKIINSIVDLVKESSGPIIEIGPGSGALTHPLSRLGRPITAV
EVDAKLAAKLTKKTASASVEVVHGDFLNFPLPATPCVIVGNIPFHLTTAILRELLHAPAW
TDAVLLMQWEVARRRAGVGASTMMTAQWSPWFTFHLGSRVPRSAFRPQPNVDGGILVIRR
VGDPKIPIEQRKAFQAMVHTVFTARGRGIGEILRRAGLFSSRSETQSWLRSRGIDPATLP
PRLRTSDWIDLFQVTGFSPPRHRPISQSGSSQRPPQRKKRGRRR
Function This enzyme introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine1518 and adenine1519 in 16S rRNA. And Strains lacking the methylase are resistant to kasugamycin.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          1 Drugs
Tacrolimus
 Drug Info Approved Ulcerative colitis ICD11: DD71 [1]
      Preclinical/investigative Agents Click to Show/Hide the Full List of Drugs:          1 Drugs
Pentamycin
 Drug Info Investigative Candidiasis ICD11: 1F23 [1]
References
1 High frequency of macrolide resistance mechanisms in clinical isolates of Corynebacterium species. Microb Drug Resist. 2010 Dec;16(4):273-7.

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