Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1242)
DME Name NADPH-dependent oxidoreductase (nfrA), Staphylococcus aureus
Synonyms NADPH-dependent FMN and FAD-containing oxidoreductase; Novel reductase 1; SAOUHSC_00366; nfrA
Gene Name nfrA
UniProt ID
NRFA_STAA8
Gene ID
3919785
EC Number    EC: 1.6.5.2     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
NADH/NADPH oxidoreductase
Quinone acceptor oxidoreductase
EC: 1.6.5.2
Lineage    Species: Staphylococcus aureus     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Bacillales
Family: Staphylococcaceae
Genus: Staphylococcus
Species: Staphylococcus aureus
Interactome
(loading-time for this interactome depdends on the speed of web connection)
       Interactions between Xenobiotics and DME (XEOTIC)                      
Jump to Detailed Interactome Data                      
       Interactions between Host Protein and DME (HOSPPI)                     
Jump to Detailed Interactome Data                      
      Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution Primarily distributed in human gut.
Sequence
MSEHVYNLVKKHHSVRKFKNKPLSEDVVKKLVEAGQSASTSSFLQAYSIIGIDDEKIKEN
LREVSGQPYVVENGYLFVFVIDYYRHHLVDQHAETDMENAYGSTEGLLVGAIDAALVAEN
IAVTAEDMGYGIVFLGSLRNDVERVREILDLPDYVFPVFGMAVGEPADDENGAAKPRLPF
DHVFHHNKYHADKETQYAQMADYDQTISEYYDQRTNGNRKETWSQQIEMFLGNKARLDML
EQLQKSGLIQR
Pathway Metabolic pathways (sao01100 )
Riboflavin metabolism (sao00740 )
Function This enzyme reduces FMN, organic nitro compounds and disulfide DTNB. And it is involved in maintenance of the cellular redox state and the disulfide stress response.
Full List of Drug(s) Metabolized by This DME
      Drugs Approved by FDA Click to Show/Hide the Full List of Drugs:          2 Drugs
Nitrofurantoin
 Drug Info Approved Infectious cystitis ICD11: GC00 [1], [2]
Riboflavin
 Drug Info Approved Acne vulgaris ICD11: ED80 [1]
      Drugs in Phase 3 Clinical Trial Click to Show/Hide the Full List of Drugs:          1 Drugs
Nitrofural
 Drug Info Phase 3 Acute tonsillitis ICD11: CA03 [1], [2]
References
1 Reduction of polynitroaromatic compounds: the bacterial nitroreductases. FEMS Microbiol Rev. 2008 May;32(3):474-500.
2 The human gut microbiota: metabolism and perspective in obesity. Gut Microbes. 2018 Jul 4;9(4):308-325.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.