Details of Drug-Metabolizing Enzyme (DME)

General Information of DME (ID: DME1278)
DME Name	Unclear metabolic mechanism (DME-unclear), Lactobacillus acetotolerans
Gene Name	DME-unclear
Lineage	Species: Lactobacillus acetotolerans (Click to Show/Hide the Complete Species Lineage) Kingdom: Bacteria Phylum: Firmicutes Class: Bacilli Order: Lactobacillales Family: Lactobacillaceae Genus: Lactobacillus Species: Lactobacillus acetotolerans
Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME
Tissue Distribution	Primarily distributed in human gut.

Full List of Drug(s) Metabolized by This DME
Drugs Approved by FDA			Click to Show/Hide the Full List of Drugs: 2 Drugs
Metamfetamine	Drug Info	Approved	Attention deficit hyperactivity disorder	ICD11: 6A05	[1]
Oxtriphylline	Drug Info	Approved	Congestive heart failure	ICD11: BD10	[2]
Preclinical/investigative Agents			Click to Show/Hide the Full List of Drugs: 3 Drugs
Kalopanaxsaponin I	Drug Info	Investigative	Prostate cancer	ICD11: 2C82	[3]
Kalopanaxsaponin J	Drug Info	Investigative	Discovery agent	ICD: N.A.	[3]
Phosphatidylcholine	Drug Info	Investigative	Discovery agent	ICD: N.A.	[2]

References
1	The demethylation of methamphetamine by intestinal microflora. J Pharm Pharmacol. 1973 May;25(5):422-4.
2	Resveratrol attenuates trimethylamine-N-oxide (TMAO)-induced atherosclerosis by regulating TMAO synthesis and bile acid metabolism via remodeling of the gut microbiota. mBio. 2016 Apr 5;7(2):e02210-15.
3	Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites. Biol Pharm Bull. 2002 Jan;25(1):68-71.

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